It's wonderful

[Andiamo1]

When I first started reading this forum, most of the eot+12 week results were relapse.  Now they are overwhelmingly SVR.  This realization has made my day!!!

[Willy50]

There has been a slew of SVRs here lately eh?  I think it's the wave of the future.

Our population is going to diminish due to SVR's.  

best,
Willy

[Isobella]

I sure hope to be part of that new wave.

[lapis]

It is awesome, huh?  Gratitude abounds.

Lapis

[frijole]

Are your observations from the posts you have read?  What do you attribute this wave of SVR too?  Is it postings by PI trial participants or is it that that there is more acceptance and subsequent treatment of 72 weeks based on detectable VL at 12 weeks.  I would like to believe this is fact and have not been reading the forum much and have lost the flavor of it, so to speak.

frijole

[Andiamo1]

Yes, my observations are from posts I have read.  I attribute it to a number of things: new drugs, weight based riba,  varying length treatments based on time to undetectable status.

Since my observations are based on this forum, it is obviously far from a regorous scientific study.  It is very possible that since people here are better informed, they will make better treatment choices and therefore have a higher SVR rate than the general public.

It is also possible that people that relapse are not as vocal as the SVRs. So, I have opinions and next to no facts.  Not so different from the world leaders - LOL.
Eric

[Isobella]

I attribute my UND at12 weeks post to weight based Riba and no fibrosis.  At least that's the consensus until I'm unblinded, but my trial had no arm that went 48 weeks and got the tela...so that't my theory.

[GreatBird]

I've been reading this forum off-and-on since 2002 and to me one of the very most significant things is the testing thresholds are so much lower now so more effective tx decisions can be made. It used to be that testing went to <615 and it was considered UND below that.  

Also, from what I can tell, tx is being tailored to the individual by more doctors now than it was then.

There is so much more understanding all around about how tx works (and doesn't) and it's such a good thing. I know we still have a lot to learn, though, and that will make for even more successful and easier tx's ahead.

[nygirl7]

I agree that it is defintely true.  I believe the more tailored treatment is certainly helping (weight based riba, extensions) as well as knowing which are true UNDs and not.  We have had a few relapses that were due to people who were not even UND at week 24 but beyond...and those shouldn't really be included in the "relapse" portion in my opinion because they are outside all the usual parameters and shouldn't have continued in my opinion as extention doesn't seem to work if you are not UND by then.

With the advent now of the PIs the relapse/breakthroughs are down even more than they were before.

Just goes to show that the most educated patient generally does have the better chance at success....using all the tools we have DOES improve the odds vastly!

[Isobella]

So true...the increased sensitivity of the thresholds is huge also.  

Seeing that they were <615 in the past is mind blowing....

I wish SVR for us all..  One day sooner rather than later.

[Rosebud41]

Can you list a few of the tools you consider important as it relates  to success with treatment?
I want to see if I'm missing anything.

Rosebud41