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http://www.cumc.columbia.edu/dept/gi/autoimmune.html
There may be cases where due to some malfunction of the immune system, it may start attacking the liver with no history of viral hepatitis.
If during treatment the liver enzymes go up instead of down, it is worth testing for autoimmune response. I had a test which showed a weak auto-immune response, but it was enhanced during IFN tx and I didn't respond.