I have heard that there is a grading system for cirrhosis. I believe the ranges went from 1 to 4. Is there such a system and how is each determined? Does 1 represent slight damage and 4 macronodular damage?
I appreciate your question because it gives me an opportunity to talk about grading systems for liver biopsies.
I always stress to my readers that when I look at a liver biopsy, I am more concerned about the amount of scarring and I am less concerned about the amount of inflammation. This is because, it is the scarring that really damages the liver. We call the scarring, fibrosis in medical terms. Cirrhosis is an advanced form of fibrosis.
We measure degrees of fibrosis by a variety of measuring systems. However, one of the simplest and one of my favorites grades fibrosis uses a scale of 1 to 4. Fibrosis usually begins around a part of the liver called the portal tract. Using this system, grade 1 does represent mild fibrosis. Grade 2 represents significant periportal fibrosis (inflammation confined to the area around the portal tracts). Grade 3 usually refers to fibrosis that extends from one portal tract to another. The fibrosis bridges one portal tract to another and is called bridging fibrosis. Grade 4 refers to cirrhosis which is the most advanced form of fibrosis.
I hope this information is helpful to you but I do feel it is critical that you go over the biopsy results with your physician. It is easy to misinterpret results and what they mean. Please let me know if you have any additional questions or information. You can get back to us through MedHelp or you can contact us directly at (313) 916-8865. At Henry Ford, we have an active group of liver specialists with a strong experience and interest in hepatitis C.
This response is being provided for general informational purposes only and should not be considered medical advice or consultation. Always check with your personal physician when you have a question pertaining to your health.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.