From the liver function test which shows elevation of AST and ALT and the fact that you are on lamivudine, I presume that you had chronic hepatitis b.
The interpretation of your current report will require previous data from your liver function tests, HBV DNA titer, HBeAg and ultrasound report.
Do get back to me with these reports so that I can answer your question satisfactorily.
Hope that this information helps and hope that you will get better soon.
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My previous LFT is all normal. I actually happened to test ALT four days ago before the above report. It was 42. (But I did not test AST). I tested every four months and I normally has ALT <40.
My last DNA report was one year ago, with undectable.
My HBeAg is -ve (the same time with the above report). Ultrasound report is mainly normal. But I have fatty liver, but I always have fatty liver.
Moreover, I felt great and do not any symptom yet. I really do a lot of exercise try to stay fit. Went to gym 2-3 times per week. However, also have ate more and actually surprise to find that I gain weight and fat ratio in my body.
Hope this provide your more information. Thanks for your answer, doctor.
Yes, I was HBeAg positive before taking lamivudine, archieved HBeAg negative about 2-3 years later. My doctor decided I should continue taking the med and it has been about 8 years since I started taking it.
Technically we call a person with HBsAg positive and with normal ALT and negative HBeAg as a carrier. Normally carriers are not treated, but your doctor must be having a sound reason to put you on Lamivudine therapy. It can be chronic Hepatitis B. You should try to find with your treating doctor and provide the final diagnosis.
The recent rise in ALT & AST ( Alanine & Aspartate Aminotransferase) may indicate one or more of the following:
1. You may have developed resistance to Lamivudine which is very common. Mutation analysis may clear this opinion
2. You may be developing Non Alcoholic Steatohepatitis (NASH)
3. You may be exposed to any other infection / medicines which can rise temporarily raise the ALT. You can wait and repeat the tests following your doctor’s advice.
Hence you can speak to the treating Hepatologist / Gastroenterologist about mutation analysis / Lamivudine resistance testing. A liver biopsy is required to know the status.
Hope this information helps and hope that you will get better soon.
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