Re: ALT & GGT levels

Posted By Richard on July 25, 1999 at 19:37:24
I was diagnosed with hepatitis C June 1998. July 98 quantitative HCV RNA level was positive 570,000 copies. Liver biopsy revealed no fibrosis or cirrhosis and revealed only very mild inflammation.
I began combo treatment (interferon/ribavirin) on Sept. 98 Treatment was discontinued after 24 weeks (Feb. 99) and RNA level was 542960 and ALT was 164.
My ALT was: 89/81, 90/75, 92/59, 94/48, 95/59, 96/50,97/74, 6-98/80. After 2weeks of combo treatment my ALT went up to 130. Two weeks later new RNA was 273,000 and ALT was 94.Then on 12/4/98 Alt went up to 110, 1/12/98 ALT was 121,and now 6 mos. later my ALT is 82.
Question #1: Is combo treatment the reason I saw such a rise in my ALT, since it went back down after treatment?
My GGT levels were: 89/146, 90/195, 92/126, 94/108, 95/146, 96/222, 97/245, 98/173, 99/228.
Question #2: Why has it not fluctuated like my ALT? Should I be concerned about something else?
Thank you for your help and time.....Richard

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Posted By C on August 02, 1999 at 00:28:20
If you were taking nsaids, ibuprofen or aspirin to combat side affects of interferon, I've been told that can cause liver damage itself and possibly explain ALT levels raised during treatment?










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