Re treat or not re treat?

Dear Dr Dietrich,

I have had a hepatitis in 1976 - then they only differenciated A and B and I was diagnosed non A nonB - some 30 years later after thinking I had rheumatism I found out that I has Hep C still active and acute (genotype 1). I started treatment in the summer of 2006 (peginterferon 180 and ribavrin 1000) and spontaneously responded - my viral load was eradicated after 3months and remained negative, but we had to cut down the interferon to 135 because of my low platelets. I was treated until october 2007 and a couple of weeks later I relapsed. My status today (from france):
I recently did an Actitest Fibrotest : score F3 (0;68) A1 (0.30)
Alpha Macroglobilin (g/l) 3,50
Apolipoprotein A1 (g/l) 1,53
Bilirubin (microMol/l)
Haptaglobin (g/l) 0,20
Gamma GT (Ul/l) 30
ALAT (Ul/l) 34
I tested positive on rheumatoid factor 29,7 UI/ml
Waler/rose positive 10UI/ml
Antinuclear antibodies positive (80)
and Cryoglobuline after 7days at 4°C is positive too (weak)
my viral load is at 681 673 UIVHC/ml (5.8 log)

I will go to the hospital on june 30th for a biopsy, endoscopy and colonoscopy -

I am quite ready to try treatment again but my doctor is seemingly reticent - I don't know what to do
By the way I am 52 years old ... thank you so much in advance
Béatrice

[Douglas Dieterich, MD]

Too early to tell what to do until we have biopsy back. However if your platelets were low you may have significant liver disease. You will also be a good candidate for the new drugs for HCV, telapravir being the first one on the market or the mostly likely to have a clinical trial near you. Good luck! Get back to me with biopsy results. DTD