Hepatitis Expert Forum
Relapsed, from Roche R1626/Prodrug
About This Forum:

Questions posted in the Hepatitis Forum are answered by medical professionals and experts.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
This expert forum is not accepting new questions. Please post your question in one of our medical support communities.
317787 tn?1463415842
Relapsed, from Roche R1626/Prodrug
Hello, I am a 52 year old 140 lb female.  I am a Geno Type 1A  with Grade 2 Stage 4 .   When I started treatment on 2/1/08 my viral load was 12M, within 8 weeks of the triple combo I was undetectable. I took 180iu of peg (reduced to 135 after 4 weeks), 1000 Riba and 1000mg of R1626 (16weeks) I continued to be undetectable until I  had to stop treatment due to dangerously low lymphocytes and CD3/CD4 on Nov 26 2008; after having done 43 of 48 weeks.  On Jan 2nd the blood work showed I relapsed and my viral load was 4M.  I would like to know how long I should wait to retreat.  How should I retreat? I  wonder if I had been able to take the full dose of the Peg if I would have had a better chance.  The Prodrug affected me so badly that they had to reduce the Peg.  I have not taken the R1626 since June of 08, it is now Jan 09 and my immune system is still affected
I would appreciate any advice or information you can share.  My doctor said that it would be a waste of time to try 48 weeks of SOC since I took that however I really didn't 135iu is not 180 and 43 is not 48.  I have been told that because I am stage 4 I will need to treat more aggressively or maybe longer.   I am very confused and afraid.  
Thank you
Dorene
Discussion is closed
Cancel
4 Answers
Page 1 of 1
517294 tn?1212081606
I would wait as well with this one. This drug has had some bone marrow effects and they seem to last a long time. You may be able to qualify for a protease trial or one of the two proteases when they get approved in 2011. Certainly rushing to treat now would be a mistake. Take some time off and cure your liver, your marrow and your soul. then we can deal with this next year.
DTD
Discussion is closed
Cancel
317787 tn?1463415842
Thank you very much, I have been through a year from hell and everyone, family and friends are telling me I need to treat right now because of my transitioning to cirrhosis
Study doc not helpful.  Thank you so very much!
Dee
Discussion is closed
Cancel
Avatar universal
A related discussion, car accident was started.
Discussion is closed
Cancel
Avatar universal
A related discussion, hep c and marijuana was started.
Discussion is closed
Cancel
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank