Posted by donald on May 26, 1999 at 10:10:12
This is a follow-up to my earlier posting of April 24. My wife's gastroenterologist told us today that highly elevated ANA levels can occur with autoimmune hepatitis even though enzyme levels are almost normal (about 50). My research in Medline has failed to locate any published reference to this. The ANA level has risen from 1:640 last August to 1:2560 this March.
Your comments would be appreciated.
Posted by HFHSM.D.-D.M. on May 31, 1999 at 16:51:43
I appreciate your follow-up correspondence. Your gastroenterologist is correct in that an individual can have autoimmune hepatitis with a markedly elevated ANA and only have mild elevations of the ALT and AST. While the ALT and AST are usually good markers of disease activity and we monitor them to assess disease activity, in a minority of patients they do not correspond well to the severity of disease. For this reason, we often find a liver biopsy is helpful in sorting things out and establishing both the diagnosis of autoimmune hepatitis and the severity of disease.
It is hard for me to point you to a specific reference. Probably the best thing is for you to check out some of the liver disease textbooks which you can get any medical school library. I would recommend
Copyright 1994-2016MedHelp International.All rights reserved. MedHelp is a division of Aptus Health.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.