My doctor said it's not definitive/conclusive, but I tested negative for HSV2 IgG (result didn't specify the indication level) 8+ weeks after initial diagnosis, 10+ weeks after possible initial exposure and was wondering what conclusions to actually draw.
Reading http://www.biokitusa.com/NCCLS_BK_HSV-2_Whole_Bood.pdf it seems like it's in the 85%-95% ranges, but I'm not fully clear on how to interpret sensitivity and specificity (I guess I should look at the sensitivity since I'm concerned about a false negative).
Background: Had unprotected sex w girlfriend, 2 weeks later got what looked like zits on my shaft underneath the foreskin, went to the doctor, doctor says it's herpes but the presumed vescicles don't really have any liquid in them, nor do they ulcerate and crust (and the virus culture came back negative, as the doc said to expect).
About two months later I go back for a blood test, which comes back negative, but the doc says it's not conclusive - "it'll tell you if you have it, but won't tell you if you don't" kind of thing.
I haven't had any more outbreaks, but I'm obviously concerned about my health and what to tell future partners.
Is there any other test I should have done to get a conclusive diagnosis?
Reading the biokit PDF document, it says some confusing things on p6:
"The biokitHSV-2 Rapid Test detects antibodies to HSV-2 glycoprotein G (gG2)" ... blablabla ... "antibodies to this protein as detected by EIA or Western blot, may not be produced for up to 6 months after acquisition of HSV-2."
"Seroconversion can vary anywhere between 21 to 40 days"
"the median time detection of HSV-2 antibodies by the biokitHSV-2 Rapid Test was 13 days"
"HSV-2 specific antibodies usually appear in patient serum within a week of infection reaching peak levels in 4 to 6 weeks"
So far it seems like the test should be definitive at six _weeks_ - the six _month_ figure seem to apply to something slightly different. However, there's also the ever-so-reassuring disclaimer further down on that page:
"Some patients may not develop detectable antibody titers after infection and in others; antibody levels may fall to very low or undetectable amounts"
"the lack of antibodies to HSV-2 does not exclude the possibility that the individual is infected with HSV-2."
It leaves you with a lot of anxiety for not a lot of good reason. If your last negative result was 6 months after the last time you had sex with anyone, there's absolutely no reason for any continued testing. if it was only 2 months since the last time you had sex, then repeat it in 2 months as I already suggested.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.