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Integrative Fertility (Expert Forum)
Chromosomal reasons for recurrent miscarriages
Answered by
John H. Kim, M.D. - Women's Health, Gynecology, Acupuncture, Integrative Medicine, REI, Mind/Body Medicine, ReproductiveMedicine, IntegrativeFertility, Herbal Medicine, infertility, menopause
John H. Kim, M.D.
Los Altos - CA
This forum is for questions and support regarding an integrative approach to healing that combines the best practices in complementary and conventional medicine. Topics include: Acupuncture, Herbal Therapy, Mind/Body Medicine, Traditional Chinese Medicine, Fertility, Stress and Fertility, Body Weight and Fertility, Environmental Contaminants and Fertility, Polycystic Ovarian Syndrome, Recurrent Pregnancy Loss, Fibroids, Endometriosis, Hormone Imbalances, Menopause.
Chromosomal reasons for recurrent miscarriages
by bny807, Jan 06, 2009 11:02AM
Hello! we have had several miscarriages while undergoing fertility treatments.. we recently had chromosomal testing (my husband and myself) along with the coagulopathy testing.. something has come back positive, and we are waiting for our appointment to hear what it is.. our miscarriages have never been similar (one chemical, one blighted ovum with no bleeding until almost 12 weeks, and then one where the beta was more than doubling every 48 hours but i was bleeding the whole time and miscarried at 6 weeks) i thought since they were all so different that it was not likely there would be something that showed up positive on this testing.. do you know what other chromosomal abnormalities they check for besides translocations? they only took one tube of blood from my husband.. Thanks so much for your time, its greatly appreciated!!
Doctor's Answer
by John H. Kim, M.D., Jan 06, 2009 08:21PM
, Jan 06, 2009 08:21PMTo: bny807
No I don't think taking a aspirin 81mg it too late. It may be better late than never.
For chromosomes the most common is balanced tranlocations but there can be any number of rare chromosomal anomalies that have been associated with recurrent pregnancy loss.
This is from the ASRM Patient fact sheet:
"Genetic/Chromosomal Causes. A chromosome analysis performed from
the parents’ blood identifies an inherited genetic cause in less than 5% of
couples. Translocation (when part of one chromosome is attached to
another chromosome) is the most common inherited chromosome abnormality.
Although a parent who carries a translocation is frequently
normal, their embryo may receive too much or too little genetic material.
When this occurs, a miscarriage usually occurs. Couples with
translocations or other specific chromosome defects may benefit from
pre-implantation genetic diagnosis in conjunction with in vitro fertilization.
In contrast to the uncommon finding of an inherited genetic cause, many
early miscarriages are due to the random (by chance) occurrence of a
chromosomal abnormality in the embryo. In fact, 60% or more of early
miscarriages may be caused by a random chromosomal abnormality,
usually a missing or duplicated chromosome."
For chromosomes the most common is balanced tranlocations but there can be any number of rare chromosomal anomalies that have been associated with recurrent pregnancy loss.
This is from the ASRM Patient fact sheet:
"Genetic/Chromosomal Causes. A chromosome analysis performed from
the parents’ blood identifies an inherited genetic cause in less than 5% of
couples. Translocation (when part of one chromosome is attached to
another chromosome) is the most common inherited chromosome abnormality.
Although a parent who carries a translocation is frequently
normal, their embryo may receive too much or too little genetic material.
When this occurs, a miscarriage usually occurs. Couples with
translocations or other specific chromosome defects may benefit from
pre-implantation genetic diagnosis in conjunction with in vitro fertilization.
In contrast to the uncommon finding of an inherited genetic cause, many
early miscarriages are due to the random (by chance) occurrence of a
chromosomal abnormality in the embryo. In fact, 60% or more of early
miscarriages may be caused by a random chromosomal abnormality,
usually a missing or duplicated chromosome."
Member Comments (2)
by bny807, Jan 06, 2009 04:47PM
update: so today i took a pregnancy test that is faintly positive - however its 13 days after my IUI.. so it should be darker i think (i've had similar using same tests and my beta was 15) i called the dr and they said to go ahead and take an asprin now.. 81mg.. but isn't it too late? can it help after you've already gotten a positive test? thanks again so very much!
