Adverse events have been reported very rarely in patients with nickel allergy who have PFO closure devices that contain nitinol. A bio-absorbable( Bio-STAR ) device is being evaluated in
animalAnimal shape vitamins
Animal shape vitamins with iron models and in a Phase I trial. There have been reports of PFO closure using Radio-frequency energy delivered to seal the PFO. PFO's can also be treated surgically. Unfortunately, there is not much data to advise you on this problem