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Lymph node swelling as a result of most cancers (such as Hodgkins) is often painless for a long time since cancer is great at masking itself under the guise of your immune system--thus, your lymph nodes become swollen with cancerous cells your body doesn't identify as "bad", so there is no pain. Swelling of lymph nodes as a result of HIV, mono, and other infections tend to cause some pain or soreness. It's also important to note that cancerous lymph nodes generally begin as a single, isolated node or two, and the nodes are hard or firm upon touch. HIV and mono generally cause a widespread swelling of lymph nodes (inguinal, axillary, cervical, etc.).
Lymph node swelling as a result of most cancers (such as Hodgkins) is often painless for a long time since cancer is great at masking itself under the guise of your immune system--thus, your lymph nodes become swollen with cancerous cells your body doesn't identify as "bad", so there is no pain. Swelling of lymph nodes as a result of HIV, mono, and other infections tend to cause some pain or soreness. It's also important to note that cancerous lymph nodes generally begin as a single, isolated node or two, and the nodes are hard or firm upon touch. HIV and mono generally cause a widespread swelling of lymph nodes (inguinal, axillary, cervical, etc.).
I hope this helps!