"Is the portal hypertension most oftenly caused by cirrhosis? " Yes, I believe that it is.
Lipitor? Statins have been associated with elevated liver enzymes. The correct protocol for a prescribing physician is to order blood tests and specifically liver enzymes (ALT, AST, GGT) BEFORE starting a statin. This gives the doctor a baseline against which to measure possible elevations. Blood should be checked a month or 2 after starting the statin to look for any elevations. I haven't read everything on this topic so I'm just going off the top of my head here but I recall that the elevated liver enzymes associated with statins rarely resulted in liver damage. If the elevation is significant a different stain can be substituted because different statins can impact the patient differently. Anyway, blaming it on Lipitor just seems too simple and if that were really the case why wasn't the prescribing doctor monitoring him closer. This type of thing doesn't happen over night. Didn't anyone notice his ascites or his yellow color before his admittance to the hospital? I am not trying to lay blame here but I am a bit reluctant to buy the Lipitor theory. He had to be getting prescriptions and he should have been monitored so that this type of thing wouldn't occur.
Mike
Thank you Mike. None of the doctors actually said that he had cirrhosis. He had a biopsy done, but never said cirrhosis. They thought that even though it didnt show cancer, they said that if they would have opened him up they would probably find it somewhere. His sister died of liver cancer. We were told that he died of liver failure caused by Lipitor. The last year I seen him tire easy. He just didnt have any spunk. He went to the ER because of terrible pain in the right side of his ribs. They gave him Vicodin and told him that he had kidney stones. The Vicodin is what really put the clinkers to it all. He almost immediately turned jaundice and went down hill from that. Is the portal hypertension most oftenly caused by cirrhosis?
Yes, I've heard of it.
The internal bleeding is often the result of ruptured varices.
With cirrhosis the portal pressure increases. Cirrhosis results in a greater resistance to the blood flowing into the liver and it then seeks alternative routes that are less restrictive. The blood can flow into the vessels in the esophagus. The vessels can then become distended and are prone to rupture. Varices can also develop in the stomach - gastric varices - and can also rupture. They can burst which causes a major bleed or in other cases they can trickle blood. This blood in the stomach becomes dark and has a coffee ground appearance. This is not uncommon with late stage cirrhosis and if your Grandfather had ascites and edema and was jaundiced then it is likely that he was in end stage liver disease.
Mike
I guess there isnt anyone thats ever heard of this, huh!