Liver needle biopsy specimen with minimal portal inflammation, minimal interface hepatitis and rare foci of parenchymal necroses. Ground glass hepatocytes are not identifiable,
Trichrome stain shows portal fibrosis and fibrous septum formation.
Iron stains show no Iron deposits.
Immunostains for HBsAG and HBcAG are in progress,
Comments: Findings are in consistent with chronic Hepatitis B with minimal activity(grade 1 of 4) and fibrous septa (stage 2 of 4)
Immunohistochemical stains: There are islands of HBsAg positive hepatocytes with membranous and sub-membranous expression and small number of cells with cytoplasmic HBsAG; rare hepatocytes have HBcAG in nuclei and cyptoplasm. The findings are those of HBsAG predominance pattern with low Viral Replication.
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