My GGT (gamma glutamyl transferase) is 388. What could cause this? I do not drink alcohol and do not smoke. A few weeks ago I had some stomach pain and a feeling of nausea but not now. Those are my only symptoms. Any ideas?
High levels of GGT and AP hint at a possible blockage of the bile ducts, or of possible injury to, or inflammation of, the bile ducts. This type of problem is characterized by an impairment, or failure, of bile flow, which is known as cholestasis. This type of liver injury is known as cholestatic liver injury, and this type of liver disease is known as cholestatic liver disease. (Primary biliary cirrhosis, discussed in Chapter 15, is an example of a cholestatic liver disease.) Intrahepatic cholestasis refers to bile duct blockage or injury within the liver. Intrahepatic cholestasis may occur in people with primary biliary cirrhosis or liver cancer (see Chapter 19), for example. Extrahepatic cholestasis refers to bile duct blockage or injury occurring outside the liver. Extrahepatic cholestasis may occur in people with gallstones.
When a blockage or inflammation of the bile ducts occurs, the GGT and AP can overflow like a backed up sewer and seep out of the liver and into the bloodstream. These enzymes typically become markedly elevated—approximately ten times the upper limit of normal.
GGT is found predominantly in the liver. AP is mainly found in the bones and the liver but can also be found in many other organs, such as the intestines, kidneys, and placenta. Therefore, elevated levels of AP will indicate that something is wrong with the liver only if the amount of GGT is raised as well. Keep in mind that, GGT can be elevated without AP being elevated, as GGT is a sensitive marker of alcohol ingestion and certain hepatotoxic (liver toxic) drugs. It should be noted that for unclear reasons, people who smoke cigarettes appear to have higher AP and GGT than nonsmokers. Also, levels of AP and GGT are most accurate after a twelve-hour fast. You are beginning to get an inkling of the complexities that arise when evaluating abnormal LFTs!
Normal levels of AP range from 35 to 115 IU/L and normal levels of GGT range from 3 to 60 IU/L. Some causes of elevated AP and/or GGT include the following:
GTT (gamma glutamyl transpeptidase) is often elevated in those who use alcohol. But it is also elevated due to liver-toxic substances like paracetamol. It's likely that the medications you had used for the abdominal pain could have caused this elevation. Please re check these values to study their progression.
Two years ago I partied super hard on vacation. My leg got really swollen. When I got home I went to the doctor. I had a liver function test and it showed my gamma gt (ggt) to be 128. The doctor said to stop drinking alcohol for 3 months and it would return to normal. So, I stopped drinking for 3 months.
I got tested again after abstaining from alcohol for 3 months. Now, my liver function tests showed gamma gt at 320! So, I went for an ultrasound and it was negative for fatty liver.
For the next few years my gamma gt was elevated despite abstaining from drinking alcohol for months and months.
I concluded alcohol was not the reason for elevated liver enzymes like ggt. So, I picked up a book for an 8 week liver cleanse diet. I stopped eating fast-food, dairy, refined sugar products, and meats (except free range chicken). I juiced everyday in the mornings and drank 3 litres of water a day. After just completing 5 weeks of the diet, my gamma gt and all other enzymes returned to normal!
My theory is my gamma gt was elevated due to eating fast-food and drinking way too much diet cola. It had nothing to due with alcohol consumption.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.