Yes, if you mean in the short-term. See, the liver is is like a bouncer, tossing all the incommodious. One night, there might be 4 objectionable patrons, while another could yield a number greater-than, equal-to, or less-than the arbitrary number of 4. Be vary wary of the barfly though.
For fear of sounding pretentious, or speaking under the questioners query: A spike in a specific dehydrogenase enzyme is plausible, as is a decline in certain activity-functioning enzymes. Moreover, habitual use will **** you up brotha!
Although abstinence from such harmful chemicals is greatly recommended, it is important that one seek, and find information on the topic.
My recommendation is to use the information provided, and pursue local guidance for further elaboration. I recognize this step may be embarrassing, or even ego-altering, however, there's nothing more deflating than friends and family reminiscing profound moments that once included you.
P.S. If you're trying to get out of a drug test...good luck. Some pass, and some fail. It all depends.
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