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liver disease
why do patients with liver disease often dvelop blood clotting disorders
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One of the signs of advanced liver disease is a low platelet count. Bone marrow can become impaired and thus fewer platelets are prodiced and often the spleen will sequester many of the circulating platelets. An enlarged spleen in a setting of liver disease in often a result of sequestered platelets. Platelets are a critical factor in the clotting process and a low platelet count can negatively impact clotting. This explains why some routine invasive procedures are more difficult and riskier when the platelet count is too low - liver biopsy, for instance, out of fear that the patient may bleed.
Mike
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