My husband had Hep C and was treated successfully in 2008. Since then, labs slowly declining. MELD was an 11 at start of treatment, has recently risen to a 20! No docs can figure out why things are getting worse despite clearing the virus. He drinks NO alcohol at all, eats relatively well, sneaks an occasional cigarette but it not a heavy smoker. He has been tested for other liver diseases and all negative. Any thoughts as to what could be happening? He's been seen by liver specialists at Hahnemann Hospital and UPenn in Philadelphia - no answers except now its time to evaluate for transplant. We were told to expect liver to remain stable and even get a little better after SVR. Have you ever seen this happen?
i am not really sure why unless he has baseline fatty liver that has worsened. Creatinine assesses renal function and is a prt of the MELD equation so its also possible that the increase in MELD is reflective of worsening renal function as opposed to worsening liver functions.
I have what my Dr. says is "persistence of cirrhosis" I did one of the victrellis trials and am SVR for almost 2 years now. I developed HE after my treatment and have a few varices.(grade 1) At least if I end up transplanting I won't have the virus anymore. Meld is 12. Have you heard of this?
Thanks for the reply - his kidneys are in good shape - it's the bilirubin that has shot up over the years. They had never mentioned fatty liver before....our doc says in a very small percentage of people the damage progresses despite SVR, I guess we are one the the unlucky ones.
So, what do I do now? Just wait to see if it gets worse? I am monitoring for HCC every six months. My Dr. says that hopefully the cirrhosis won't progress too fast. Does that mean it will progress? I guess we won't really know. Watch and wait. Thanks for your comments.
Well, thank you Dr. Schiano for answering my questions. Most of the time I don't think about it too much. I do wonder what will happen though. I have had cirrhosis at least 10 years but I could be a lot worse. Sorry I jumped in your post ruby555. It seemed like we had a similar problem.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.