i had an abnormal lambda kappa ratio on a FLC test - 2.3 - normal is upto 1.65. I went to a new hema today who said she doesn't think this is MGUS or Multiple myeloma but probably an autoimmune disease such as Lupus, RA or other hormonal disease. I have done a lot of research in on this protein (they didn't do the immoxification test so don't know if I have an Mspike or not) this dr sent me for Lupus anitibody testing, RA test and a boatload of other blood tests. Just wondering - for those with Lupus do you also have this ratio out of whack?
Hi! Your second hematologist is right. Apart from MUGS, myeloma, lymphoma etc, a high Kappa/Lambada ratio can be due to autoimmune disease (including lupus), infection (persistent like TB), inflammation (IBS, Crohns, rheumatoid arthritis etc). hence, you need a comprehensive investigation to rule these out. Do discuss this with your doctor after the results of the investigations are made available. Take care!
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