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Lupus

What tests determine lupus in a person?
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434278_tn?1324709825
Lupus is dx by looking at both lab and symptoms.

There are 11 criteria for a lupus dx.  You must have at least 4 of the 11 to recieve a dx.

They are:
1. malar rash over cheeks (butterfly rash) (74%)
2. discoid rash, red raised patches
3. photosensitivity - reaction to sunlight, resulting in skin rash (50%)
4. oral and nose ulcers
5. arthritis (95%)
6. serositis - inflamation (inflammation) of the lining of the lung or heart
7. reanl disorder - excessive protein in urine and/or cellular casts
8. neurologic disorder - seizures, or psychosis
9. anemia or low white blood count or lymphopenia or low platelet count
10. positive ANA
11. positive anti-DNA or anti-Sm, or antiphospholipid antibody or false pos. syphilis test

Other symptoms are:
fever (90-95%)
abdominal pain
chest pain
shortness of breath
blood in urine
hair falling out (27%)
fatigue (90%)
muscle pain and weakness (90%)
dizziness
poor memory
headaches
poor circulation in fingers and toes
tingling in extremities
diarrhea
bloating
nausea
weight loss
blurred vision
depression
palpitations
raynauds (where fingers turn white when cold)
intollerance to cold
sore throat
lymph node swelling (50%)
...to name a few

Keep in mind that fibromyalgia, CFS, MS and lymes disease also have similar symptoms.  

Test that will be done are:
ANA
sed rate
CRP
anti-DNA
C3
C4
anti-Sm
anti-RNP
anti-ssa
anti-ssb
scl 7- antibody
centromere B
JO-1 antibody
anticardiolipin
thyroid antibody

I'm sure I have left some out.  But the best advice I can give to anybody going through this maze of diagnostic test is to SPEND TIME IN THE SUN JUST PRIOR TO YOUR DR. APPOINTMENT.  What this does is, if you have lupus, it will cause the ANA to be very elevated and help the dr. find what is wrong much faster.  I see so many people very sick for like 10 years before being diagnosed.  I was sooo sick for a year and a half....until I read here on medhelp this very thing.  My ANA went from 1:640 (which is high.....don't know why the dr. didn't think so..... to 1:2,560....which got their attention.)HELLO????  

Praying for ya kid.
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Avatar_f_tn
Hi,

My daughter was tested for Lupus. The only thing that came out low positive was antiphospholipid antibodies. What's your thought on this?

Thanks!
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434278_tn?1324709825
Does antiphospholipid antibodies point to a lupus dx?  The test results are considered fair.  I would need to do more research on what a positive reading would mean on that test.  Hopefully someone who knows more can weigh in on that.
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434278_tn?1324709825
Just because your daughter has the antibody does not mean she will have problems as a result of them.  10-30% of people w/ RA, scleroderma and other forms of vasculitis have antiphospholipid antibodies.  People w/ lupus "can" have problems w/ antiphospholipid syndrome as well.  

There is something you should look for: IgG anticardiolipin antibody - it is more likely to lead to blood clots than IgM or IgA anticardiolipin antibody.  Higher amounts of antibody also increase the risk of clots.  
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Avatar_f_tn
Hi Lori.
Sorry to hear your daughter is unwell.
What were the results on the antiphospolipid bloodtests?

May i ask has your daughter had any bloodcots? or miscarriages?

Has your daughter been tested for the ANtiphospolipid Syndrome?

If you coud post the test which was a low positive, and the reference range from the lab , that would help.

Also has your daughter been asked to go back for another bloodtest in about 12 weeks time to re-check the anticardiolipin?


I am really interested because, i suffer from the Antiphospolipid Syndrome, and it often gets Mis-diagnosed,
For some people this illness, can become a nightmare to live with, so i think with a correct diagnosis, and proper treatment then no problems which this illnes can cause, can be kept in-check.

Good Luck
Nicola
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