I will make this as simple and short as possible....
1999 I had a positive ANA at 1:80 speckled and a positive anti DNA of 3.7 (anything over 3.5 was highly indicative of SLE)
normal c3 c4
neg sed rate & negative RFactor, normal CRP
I have pernicious anemia
in 2005 was dx with hashimotos
fast forward to today 2013
positive ANA 1:320 speckled
NEGATIVE anti DNA
C4 elevated at 0.59 range is 0.10-0.50
CK muscle elevated at 270 normal is <200
NEGATIVE extractable nuclear antibodies
TSH LOW at 0.26 range is 0.27-4.2 while on 175 mg of synthroid and 25mg of cytomel
LOW vitamin D at 60 range is 75-150
MCV 81 range 82-98
MCH 26.7 range 27.5-33.5
RDW 15.3% range 11.5-14.5
All of this autoimmune stuff is tricky. Just when they think they have it figured out, the lab work changes.
This is what I know. It takes more than labs to get a dx of lupus. You have to have some symptoms too. The speckled pattern is seen in SLE, and numerous other autoimmune diseases and in some healthy individuals who have a low amount.
Anti-DNA is VERY specific to lupus. Less than 1% of healthy individuals have a positive DNA. It usually indicates kidney involvement. So a neg. doesn't mean you don't have lupus. It just means the activity has slowed down. So you or the dr. shouldn't be looking at that as a basis of whether you have the disease or not. You also mentioned pernicious anemia. That too is one of the 11 criteria. So right there you have 3 out of the needed 4 for a dx. Many times, autoimmune diseases travel in multiples. So it's not uncommon for someone with lupus to also have another like Hashimoto thyroiditis.
You listed these symptoms:
symptoms are fatigue, hair loss, stiff joints, mood swings, irregular menstruation....
Does you joints ever swell?
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.