leukocytosis,anti ds dna

My mother is a patient of leukocytosis. after studying her last peripheral film the doctor has commented that she has non specific morphology with leukocytosis. Besides her anti ds dna sample value result is 391.69IU/ml. Are these too much serious? Is there any way to get her well?

[Dr. Kokil Mathur]

Hi!
Your mother probably has lupus. Specked ANA and presence of dsDNA antibodies confirms lupus to a great extent. If the ANA staining test is equivocal, the speckled ANA should be studied further to confirm lupus diagnosis. Anti-SM subtype of speckled ANA almost confirms lupus diagnosis, as it is rarely present in other disorders. Anti-Ro and Anti-Sm together almost confirm diagnosis.
Lupus can cause leucocytosis with abnormal WBC. Non specifc morphology can also be seen in infections such as infectious mono nucleosis. While it may not be serious, this needs to be further investigated and treated. Please discuss with your doctor. Take care!