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Oh and welcome to MedHelp.
Could lupus cause the spleen to be enlarged. The answer to that is yes.
Here is a webstie that might help.
http://www.merck.com/mmhe/sec14/ch179/ch179b.html
It tells all the conditions that can cause an enlarged spleen.
Does the antiphospholipid antibody cause blood clots? Do they think the enlarged spleen is connected to this antibody?