Thats my question! Actually I have many but we'll start slow. I was just diagnosed about a week ago. I've been through the wringer of medical issues in the last 4 months. I've had hypertension for as long as I can remember, I was diagnosed with fibro 5 years ago, just this past July was hospitalized for renal failure and was so anemic I had to be given blood. I'm on a unbelievable number of medications for everything. I just sought out a rheumy in August. Of course he ran the gamet of tests and his exact words from the begining has been "without a doubt you have fibromyalgia digenerative disk disease, and arthritis but theres more and I will find out what it is." Then I get this diagnosis that makes no sense to me. Does anyone understand it?
I've found this very helpful in order to help me help my doctor's with my diagnosis - see below!
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of several autoantibodies, formation of immune complexes (ICs), and inflammation in different organs.
•Pathophysiology of SLE is not completely understood; however, the following have been implicated
◦Apoptosis (programmed cell death) leading to loss of immune tolerance
◦Interferon-alpha (IFN-α) and plasmacytoid dendritic cells (PDCs)
◦Toll-like receptors (TLRs) through the induction of IFN--α by PDCs
•Multiple pathogenic antibodies have been discovered
◦Double-stranded DNA (dsDNA)
◦Antiphospholipid antibodies (anticardiolipin and beta-2 glycoprotein I)
•Dermatologic – malar discoid rash, photosensitivity, skin eruptions, alopecia
•Musculoskeletal – arthritis, arthralgia, myalgia
•Serositis – pleuritis, pericarditis
•Renal – nephritis
•Neurologic – seizures, psychosis, mood disorders, stroke, chorea
•Hematologic – hemolytic anemia, leukopenia, thrombocytopenia, antiphospholipid syndrome symptoms
•Cardiovascular – vasculitis, transient ischemic attack, Libman-Sachs endocarditis
•Ocular – sicca syndrome
◦Osteoporosis – probably combination of disease inflammation and steroids used in treatment
•Increased risk of hematologic cancer and non-Hodgkin lymphoma
•Hepatobiliary cancers increased in men
•Early coronary heart disease
◦Adverse pregnancy outcomes
•Immunosuppressives are currently the mainstay of therapy
•Indications for testing – multisystem disease presentation
◦Initial testing – not disease-specific but may be helpful in determining organ involvement
•CBC – anemia, thrombocytopenia, leukopenia
•Urinalysis – hematuria; indicates renal disease
•Liver transaminases – may be elevated
•BUN/creatinine – may be elevated; indicates renal disease
•ANCA – rule out vasculitis
◦Anti-nuclear antibody (ANA) test is useful as initial screen for SLE; ANA is not disease-specific and positive samples should be tested to identify antibodies specific for SLE
•dsDNA of >1:10 detected by immunofluorescence assay (IFA) – 50-60% of SLE
◦Presence of high antibody titers to native dsDNA is specific and diagnostic for SLE
•Extractable nuclear antigens (ENA)
◦Smith (Sm) antibodies – highly specific for SLE but occur in only 30-35% of cases
◦Ribonucleic protein (RNP) antibodies – not specific for SLE
◦SSA and SSB antibodies – not specific for SLE
•Histone and ssDNA antibodies – not specific for SLE
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.