Anyone with elevated aldolase?

[leilajax]

After my recent appt with my Hopkins intern, I found out that my elevated protein is aldolase and NOT amylase, as I mistakenly heard.  Better news, but still not good news.  I was just wondering if anyone else's aldolase was elevated.  It definitely explains my weight loss (due to muscle loss) and tremor, but my doc is puzzled as to why it is elevated.  He decided to order a PET scan as well to try to rule out once and for all carcinoma influences on my unrelenting nodes.  I'm sure it will come back negative, but I do appreciate the exhaustive testing.

[cave76]

"So I'll let him test everything under my insurance but still continue LLMD treatment;)"

VERY smart gal! LOL

[leilajax]

Thank you both!  I've actually done some delving into the aldolase for a few days and something very interesting just caught my eye.  NIH did a study with elevated aldolase being treated with anti-malarial meds with good res  As it turns out, I asked to be put on Plaquenil (an anti-malarial med) a few months ago and recently bumped up the dosage.  I received a text from my intern stating that last weeks aldolase retest showed normalization!  i am positive for babesia duncani, which plaquenil treats.  i wonder if my plaquenil request was a godsend;)
Nervous about that PET scan, but again I'm so glad he's thinking of everything!  He even referred me to another ID specialist at Hopkins bc he wants every infection test under the sun ran on me.  He is very hesitant on most docs instincts to start steroids.  Yet he seemingly doesn't think my Lyme Igenex results or positive babesia duncani results mean anything!  Frustrating, but he is working diligently!  *** for tat, I guess.  So I'll let him test everything under my insurance but still continue LLMD treatment;)

[cave76]

http://www.nlm.nih.gov/medlineplus/ency/article/003566.htm

I know almost nothing about aldolase but went to find out.


"The following tests are more specific indicators of muscle and liver damage:

ALT test
AST test
CPK test"

Labtestsonline also said the same.

If your ALT, AST and CPK tests were normal you might ask your doctor about this.

Your doctor is having a PET performed which may also give him/you more answers.

Good luck.

[TheLightSeeker]

leilajax, high aldolase in your blood has indeed to do with muscle deterioration, associated with muscular diseases,or liver or heart disease, but not neurological, like MS.
Did you Doctor not look into the aldolase sub-types to determine where the problem might be?
A type, when elevated, has to do with muscle disease/damage
B type, when elevated, has to do with heart, kidney or liver disease
C type, when elevated, has to do with brain damage.

Elevated aldolase type A is consistent with the weight loss, barring other factors.
Any suspicions?

Best wishes!
Niko