MTHFR (Methylenetetrahydrofolate reductase) User Group
baby aspirin and upset stomach
About This Group:

This Group was created for anyone wishing to learn, chat or share information relating to MTHFR. Many woman have suffered Miscarriage(s) and have no idea why. For some of us, a genetic mutation called MTHFR is the reason. MTHFR (or 5,10-methylenetetrahydrofolate reductase NADPH) is a genetic mutation that has 24 known variants that affects the ability to absorb Folic Acid and can cause more severe problems in health and also in pregnancy. There is much debate and dispute within the medical community regarding MTHFR and it's relationship to pregnancy loss or Recurrent Pregnancy Loss (RPL). In all the confusion, there are many ideas and treatments along with schools of thought on how to treat or deal with MTHFR.

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baby aspirin and upset stomach

Hi,

I have 2 blood clot disorders: 1 copy of MTHFR C677 mutation and protein S deficiency. Doctor found out these after 2 miscarriages. I have a healthy 4 year old boy before miscarriages. Now I am 19 weeks pregnant. I started taking baby aspirin and folgard 2 weeks before I found out I was pregnant. I am also injecting 30mg Lovenox everyday after positive pregnancy test. The pregnancy went well except bad nausea and vomittings. At 15 weeks I vomitted blood. My OB asked me stop aspirin for 2 weeks. I did and my nausea and vomitting were gone after 1 week. He asked me to resume baby aspirin after 2 weeks. I did and after 1 week I vomitted again. This time I am not sure if there was blood in it or not since I took some chocolate desert before that. I know my tummy hasn't been feeling good that day and the day before. Now I wonder if any of you had upset stomach from aspirin. I always took it with food. How long do you take them? Are there any of you only taking lovenox and folgard but not aspirin? I don't know how long my stomach can handle aspirin....

Thanks,
Tif
4 Comments
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1227139_tn?1367231533
Hello Tif,

I have the MTHFR Compound mutation of C677T and A1298C.  I am on 30mgs Lovenox twice a day, baby aspirin and 5mg Folic Acid prenatal along with B complex vitamin 100mgs.  I have had a sensitive stomach for years having had a ulcer from taking anti-inflammatory (NSAIDS) over the many past years.  Aspirin is hard on the stomach as it does the same thing as NSAIDs - irritate the stomach.  Often when that happens food is recommended but if that isn't working for you, there is something your doctor can additionally prescribe to help with irritation of stomach due to medications.  Another thing to think about is a coated low dose baby aspirin.  Mine is coated to help prevent stomach problems.  I do know that my hematologist had said that I don't really need to take baby aspirin if I am on the Lovenox but VERY IMPORTANT thing was this, if you (like me in the beginning) are only taking one dose of Lovenox per day, you are not covering off your entire 24 hours since Lovenox is very short lived in the body (only 12 hours).  So, since I was changed to twice a day it wasn't really necessary for me to also take the baby aspirin which I was taking to cover off the missing 12 hours in the beginning.  I continue to take the baby aspirin only because I don't want to change anything at all being that it has worked and I am still pregnant 21 weeks along after having 3 miscarriages before.
I would definitely ask your OB if there was a possibility of having your Lovenox twice a day rather then once so maybe you wouldn't have to take the baby aspirin if it's affecting your stomach so much.  There is no sense in having stomach difficulties (ie the vomiting which can bring up the medications if not absorbed fast enough) if it can be prevented.
Just a thought for you to consider!

In addition to anything I have mentioned, please keep in mind, that while I or others may have extensive knowledge in many areas, you should always seek professional medical advice from your own physician, as it pertains to medical conditions or concerns.

Good luck, and if you have any other questions that I can help you with, please feel free to message me directly.

Sincerely,
Sandi (Dragon1973)
MedHelp Genetics Community Leader;
Children - Special Needs Community Leader;
Down syndrome Community Leader & Ds Group Forum Founder/Moderator;
MTHFR Group Forum Founder/Moderator;
Pregnancy: June 2011 Community Leader
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Hi, Sandi,

Thank you for your reply. I called my doctor and he said stop taking aspirin until I see him next time, which is about 3 weeks away. I vomitted blood again last night. Surely I am not taking anymore aspirin for now. I remember he told me last appointment that Folgard and Lovenox are more important than aspirin so he was not worried when I had to stop for 2 weeks. I guess that goes the same this time. I also asked him if I can just up the dose of Lovenox instead of taking aspirin. He said the mechanisms of both medicine are different. One does not replace the other. So he prefers me keep taking it if my stomach can take it. I wonder what he will suggest next appointment. The baby aspirin I am taking is coated 81mg. I rarely had stomach problems before this pregnancy. And I always took the aspirin with a meal. I don't know why my stomach is so sensitive to aspirin. Did you vomit blood from it at all?

Tif
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1227139_tn?1367231533
Hi Tif,

In answer to your question at the end, No - I have never vomited blood from the baby aspirin.  I am glad your doctor clarified his reasoning for you to remain on the LD baby aspirin if you can, but obviously they should investigate why you are vomiting and if they can do anything to help prevent it.  Are you vomiting much past after taking it or shortly after?  While it makes complete sense not to stop taking it if you can take it, it also doesn't make sense to continue if you are only vomiting it right back up.  
I can't argue or comment on your doctors opinion on the necessity of taking it while also on Lovenox and I definitely agree that Lovenox and Folgard are MUCH more important rather then just the aspirin, but if he is of the opinion that they do two different things and you are not taking the aspirin to cover off the missing 12 hours, according to my hematologist, taking only one dose of Lovenox per day wasn't covering me off all day (which is where I obtained the information that it is short lived only 12 hours effectively) and why I was changed to twice a day.  I originally was on 40mgs once a day but now 30 mgs twice a day.  K10Road (our other moderator here) was also on 30 mgs twice a day - she is Homozygous A1298C.  Just a note - She just delivered a healthy baby boy 9 weeks ago after finally being treated with Lovenox and also after having 3 miscarriages also.

On the topic of sensitivity to aspirin, there is a lot of information on the topic of aspirin irritating stomachs and also causing ulcers.  So you are definitely not alone.  The thing is, some people are just genuinely more sensitive to ASA then others.  And with that sensitivity you should be very careful as you don't want to end up permanently damaging the lining of your stomach, esophagus and/or duodenum (which is where I have my small ulcer).  But again I will mention, here in Canada we have some medications that do assist with prevention of irritation if one must take a drug that might irritate the stomach.  I am not sure if you have those kinds of drugs there, but it's worth it to ask.

Hopefully that helps?  Do remember one thing though - all of this; treatments and medications and the MTHFR itself are definitely still in the early or somewhat uncharted territories so the fact that you are at least getting treated and have a doctor who is of the opinion that taking the medications is beneficial, IS Wonderfully FANTASTIC!  Keep me posted!

In addition to anything I have mentioned, please keep in mind, that while I or others may have extensive knowledge in many areas, you should always seek professional medical advice from your own physician, as it pertains to medical conditions or concerns.

Good luck, and if you have any other questions that I can help you with, please feel free to message me directly.

Sincerely,
Sandi (Dragon1973)
MedHelp Genetics Community Leader;
Children - Special Needs Community Leader;
Down syndrome Community Leader & Ds Group Forum Founder/Moderator;
MTHFR Group Forum Founder/Moderator;
Pregnancy: June 2011 Community Leader
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Sandi,

Thank you for your comment. After vomitting blood again after I got back on Aspirin. My doctor asked me to stop taking it. Also my perinatal doctor said from recently study, aspirin is not helpful with MTHFR. He said Lovenox can help but not aspirin. I did suggest to increase my Lovenox but my OB thinks that is not necessary. I had an ultrasound with my perinatal doctor 3 weeks after I stopped aspirin. Everything looks fine. Also my OB said the way to know if my placenta is working fine is to see if baby is gaining weight normally, which he is. I will have another ultrasound 10 weeks later(31 weeks). I do feel my stomach is not as good as before. It's more sensitive now. Cannot have much spice or tomatoes. I know the Folgard I am taking is also irritating my stomach but not as bad as aspirin. I take it with food and separate from my prenatal vitamin now. Thank you again for your encouragement.

Tif
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