Any others with MTHFR with positive outcomes?

After my m/c 3/28, karotype results came back with all chromosomes but my blood work showed that I was positive for homo MTHFR. I have two other children (6&9) and never had any trouble with them.  This last pregnancy I also had a low progesterone level (9.1) and lost the baby at about 15 weeks.  Is there anyone that has been here before?  I could have had this M/C from low progesterone or because of the MTHFR.  Lots of conflicting information out there on this.

[Berko]

i was also just told that i have MTHFR after going through 2 m/c. i really hope that all will be well the next time around (G-d Willing). i'm now on extra folic acid, vitamin b6, and baby aspirin (81 mg), along with my regular prenatal to keep my blood thin. once i do get pregnant the dr. will give me heparin shots (ouch!!! - but worth it) to make sure the blood stays thin and oxygen can flow to baby without any clots. I do believe that this is an easily treatable disorder, Thank G-d. I hope that we can both go on to have healthy pregnancies and babies. good luck and keep me posted.

[anxioustobeamom]

i had mine tested and they were normal. that was after i was taking 5 mg of folic acid for 6 weeks. not sure if that had anything to do with it or not.

[anxioustobeamom]

i went into preterm labor at 21 weeks with my son back in november. he didn't make it. i was diagnosed with homo MTHFR. but there is also a thought of an incompetent cervix, to which i have no signs of having. so my doctor is going with the MTHFR diagnosis. (i also bled really bad at 9weeks 2days. giant clots. the er docs and nurses all thought i m/c. so that information helps him go with the MTHFR issue) i am currently on my prenatal vitamin and 4 extra mg of folic acid. when i do get pg again, i will be put on blood thinner shots as well. which at first scared me, but i'll do it. i have no other kids, he was my first. dh and i have been trying for 4 months now. hoping this will be our month and we can try this out. to be sure though my doc will also schedule multiple level 2 ultrasounds to keep an eye on my cervix. my mother had 3 m/c after having my sister and myself, and they never gave her any answers. but back then i don't think testing for this disorder was around. we are thinking this could have been her reason. i don't know why it affects some pregnancies and not the others. i am sorry for your loss, however, i'm glad you found out something. it helps the mind. and to know that it can be treated for the next pg is nice.

[anxioustobeamom]

i went into preterm labor at 21 weeks with my son back in november. he didn't make it. i was diagnosed with homo MTHFR. but there is also a thought of an incompetent cervix, to which i have no signs of having. so my doctor is going with the MTHFR diagnosis. (i also bled really bad at 9weeks 2days. giant clots. the er docs and nurses all thought i m/c. so that information helps him go with the MTHFR issue) i am currently on my prenatal vitamin and 4 extra mg of folic acid. when i do get pg again, i will be put on blood thinner shots as well. which at first scared me, but i'll do it. i have no other kids, he was my first. dh and i have been trying for 4 months now. hoping this will be our month and we can try this out. to be sure though my doc will also schedule multiple level 2 ultrasounds to keep an eye on my cervix. my mother had 3 m/c after having my sister and myself, and they never gave her any answers. but back then i don't think testing for this disorder was around. we are thinking this could have been her reason. i don't know why it affects some pregnancies and not the others. i am sorry for your loss, however, i'm glad you found out something. it helps the mind. and to know that it can be treated for the next pg is nice.

[sam2]

Did either of you have elevated homocystine levels?  Mine tested normal.

[anxioustobeamom]

thank you. well, i inherited one gene from my mother and one from my father. i had some blood tests done, that may have not been done unless i questioned about the pathology report of the placenta. there were blood clots on the placenta and an abruption from the uterine wall, which caused my doctor to do blood work for all the blood clotting disorders. theory is a blood clot got caught behind the placenta and tore it away from the wall, causing me to go into pre-term labor. and i found out after i lost my son, that my grandmother has a clotting issue and that she goes on blood thinners before surgery or bedrest of some sort. i sometimes wonder if i knew all this before, if my son would be here with me now. but i can' t think that way. after i tested positive for homo MTHFR, both my parents were tested, and both of them tested hetero for MTHFR. so their problem isn't as bad as mine, but still will affect them with heart disease and such. so if you are homo, like i think you said you were, then you received one from your father and one from your mother. they could had been homo or hetero for MTHFR. thank you for sharing your story. it helps to know there are other people like me out there. to know i'm not the only person with this problem, and to be reassured that my doctor is saying what others say so my next pregnancy will be a success.

[Berko]

sorry for your loss - and that you had to go through labor and everything - i can't imagine the difficulty and pain you went through with that - i do know about loss though and know how hard that is so i feel with you. did your dr. diagnose you with MFHTR through blood testing or just b/c you had symptoms? it's just not clear from your post. i think the reason this disorder would affect some women and not others is because it's a genetic disorder - you either inherited the gene from your mother or your father. if you think your mother had this too then i would think from your mother. i'm actually just started to think my mother may have had this too, but i'll never really know b/c 30 years ago they probably couldn't diagnose it the way they could now and she's not alive so i can't ask her what they thought it was when she m/c a few times before getting pregnant with my older sister (i don't know if she m/c in between the two of us). we always assumed it was b/c she had diabetes (not gestational)and that it was difficult for her to carry a baby b/c of it. she did have difficult pregnancies b/c of it so we assumed this was why m/c - i guess i'll never really know, but it would be interesting to know if she had what i have. but then again it could be my father passed down this gene so who knows? i'm just glad that this can be treated with medicines, vitamins, and shots, rather than anything more invasive. i was so worried he'd find something far worse or nothing at all. not that i want to have this disorder but at least it can be treated (G-d Willing) and can have some sort of idea of why m/c. hope everything works out for you and you're holding your healthy baby very very soon!!!

[anxioustobeamom]

my mom got me a name of a hematologist. but my obgyn never said i needed to go to one. i have an appointment with a new PCP in August. I don't like the one I have now. We'll see what this one says. my other one didn't even know what i was talking about and was like "oh, it's no big deal". i wasn't going to put up with that ****.
it helps to know that i can have a healthy child. just wanted my son so badly. but, if this didn't happen, i would have never known.

[sam2]

Homocystine is what actually causes the clots.  Folic Acid lowers the levels and so there will be no clots.  I hear that you can have the MTHFR gene, but won't have clots if the homocystine levels are normal.  Hope this helps.

[sam2]

I am so sorry to hear about your loss.  I too had bleeding/spotting with this last pregnancy.  I am so scared to try again.  But if it any comfort, it is not that uncommon to have this gene mutation and while I have this, I did have two successful pregnancies and never knew I had this disorder, hence no extra folic acid or baby aspirin or heperin.  
I am supposed to make an appointment with the hemotologist, not sure why I am hesitating.

[Berko]

anxioustobeamom: I'm not so sure that i actually have the same exact thing you do - i didn't realize there were different types and levels of mthfr. i think i must be what you called heteromthfr b/c my dr. said the only thing it should effect is early pregnancy loss and that once medicating to keep blood thin it should be okay (G-d Willing). but thank you for explaining your situation b/c now i know what else to ask my dr. and double check what the disorder actually is. I'm sure now that they know what the problem is with you they'll be able to help you through a healthy full term pregnancy and baby birth. good luck and please keep me posted. hoping to hear good news from you soon.

sam2: I don't know what homcystine levels are - what do they effect? is it part of the mthfr disorder? i'm gonna try to remember to ask my dr. about that too next time i see him. i'm so thankful for this site and all of you who add to it and give so much info and advice it really helps clarify a lot of things going on. keep me posted on how you're doing - good luck.

[sam2]

Anxious to be a mom, sorry  you have wait until August!  Hope this new Dr. is better.  I am hesitating to go to the specialists becuase I really like my OB, but since he is referring me elsewhere, I guess I will make my appointments with the hemotologist and the high risk OB.  Best of luck to you and keep trying.  I turned 36 last Friday and should not have waited this long to try again, the years just slipped by way too fast. Keep me posted on how you are doing.  Thanks for your help!

Sam

[jemima_madsen]

hi there

I am currently 34 weeks pregnant and have the abnormal MTHFR genes. I am on daily FRAGMIN injections to thin my blood as I was told that my chances of a blood clot were quite high due to the fact that I had a blood clot in 2001 AND that your blood is thicker when pregnant.

I am also taking 5mg of folic acid every day as well as a pregnancy supplement and an omega 3 supplement.

I have been told by my Dr that it is safer for me to have a caesarean birth so that he can time the birth 12 hours after my last injection.

[jann44217]

I had 5 miscarriages before they found out I had mthfr. I had another one after I found out and I'm going throught the 7th one now. I have been taking my folic acid and my baby asprin. I am so frustrated. I dont know if I will ever be able to have a baby. Does anyone else feel this way?? I mean I"m no spring chicken. I'm not old I"m 35 but I dont want to be in my 40's and have a baby like my mother did with me. I dont know I sometimes want to give up. Thanks for listening. Janie

[dainsey]

I had 3 miscarriages and I also carry the MTHFR genes.  My OB put me on Heparin, baby aspirin, folic acid and Folgard and I got pregnant and had a healthy little girl :-)  We're also going to try for #2...