extremely high hcg

Posted By  hfhs.md.rcs on March 01, 1999 at 11:07:18:

In Reply to: Re: Re: Re: extremely high hcg posted by Mel Ferguson on February 28, 1999 at 12:41:23:

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  : Thank you very much for your response.  I do hope that the hcg did remain in my system to cause this chaos.  I know I have to wait for the ultrasounds and it's hard to picture any lingering hcg causing such a high level, but with me anything's possible.  Again, thank you so much for responding.  Carol
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[hfhsmdrcs]

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Dear Mel:
As you correctly point out, choriocarcinoma, the most agressive member of the trophoblastic disease group, is rare. All trophoblastic disease is related to abnormal fertilization and expression of the "male genetic messages" independent of the female genetic message.
I have encountered a patient whose husband had been the source of sperm for a hydatidiform mole in an other lady (ie: one man who had molar disease with two partners). I have no information on brothers causing hydatidiform mole in their wives: if these were identical twin brothers, then they would share genetic charactertistics that would make the argument of a "male carrier" logical.
Our understanding of the genetics of most diseases is still very early.
Chriocarcinoma is suspected when there are very high hCG levels.
Keywords: choriocarcinoma
This information isprovided for education purposes and is not a medical consultaton. If you have specific questions, please speak with your physician.