A couple of yeras ago, with my second Mirena in place, I experienced several strange symptoms - waking up in the night with tachycardia, anxiety, sweating and extremely high BP, etc. Several tests came back negative (kidney function, thyroid, etc.) The episodes vanished as suddenly as they appeared, but borderline-high hypertension persisted and I was started on perindopril erbumine 4mg once a day. In April 2009, my Mirena was taken out after 5 years in place. I loved Mirena, because my periods disappeared completely since I started using it in 1999 and I had no negative side-effects. In June 09, my period had still not returned, so my dr. did hormone levels. FSH: 90.3 IUL; Estradiol 144 pmol/L. I was post-menopausal. In retrospect, the few strange episodes might have had something to do with menopause. Isn't 48 a little young to be post-menopausal? Did the Mirena cause early menopause? Does early menopause put me at risk for any diseases? I feel great and I am very healthy except for the hypertension which is well controlled on perindopril. (My dad had HT, died of MI at 54, my mom is 75, HT since age 51) I'm not complaining, if this is menopause, I'm breezing through it. Hot flashes are rare (maybe once a week or less) and my libido is unaffected; in fact, better than ever. My husband is a happy man. I really don't need HRT, but will it protect me against any diseases? Thank you for your time.