Has anyone used premarin cream. I am just starting menopause with the hot flashes, weight gain, anxiety, etc, My GYN prescribed Avista-an estroten/progesterin pill. I took it for about 7 days and then decided the risk of heart disease and breast cancer wasn't worth it. Someone told me to try a prescription for premarin cream. I don't know if there are any side effects to it and if it is worth taking. Just wondering if anyone can give me some feedback on it. thanks