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Mental Health  (Expert Forum)
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Does the agitation side effect of Zoloft subside?
Answered by
Roger Gould, M.D. - Mental Health, Wellness
Questions posted in the Mental Health forum are being answered by Dr. Roger L. Gould, author of the Mastering Stress and Depression program and affiliated with the UCLA. Department of Psychiatry. Topics covered include anger, attention deficit disorder (ADD) , bipolar disorder , dementia , electroconvulsive therapy (ECT) , learning disabilities, memory, obsessive compulsive disorder (OCD) , panic , personality disorders, phobias , post-traumatic stress disorder (PTSD) , schizophrenia , stress , transitions, and work problems.

Does the agitation side effect of Zoloft subside?

by magpie66, Jan 19, 2004 12:00AM
I'm taking 50mg of Zoloft, after switching from 25MG of Paxil CR after taking it for 4 months and gaining over 10 pounds.  I took Paxil from 1998-00 and went from 128 to 160 pounds.  I take it for panic, anxiety and this contant need I have to keep everything in my house spotless!  Not good when you have 4 kids, 3 of which are teenage boys.  I've learned to treat the panic attacks with Cognitive Behavior Therapy and haven't really suffered one in years.  Lately I've been quite anxious and worrisome, not to mention cleaning...so my doctor suggested I get back on Paxil.  After the recent weight gain and constant hunger he switched me to Zoloft.  I've only been 2 days on 50mg after a week of 25mg daily.  Zoloft is the only medication I take.  However....I feel so easily agitated!  I know it is a side effect of Zoloft but my question is WILL IT SUBSIDE?  I don't mind continuing this med if I know this agitation will level out over time.
Somthing else I have really noticed over the past few months are these vivid dreams.  Not violent in nature but almost like watching a movie every night.  DO you think they will continue with the zoloft?  I don't remember that from the last time I took Paxil....THANKS SO MUCH!

by Roger Gould, M.D., Jan 20, 2004 12:00AM
For most people, the agitation effects does level out,but some people are extremely sensitive so you may have to continually adjust the dose if this continues.  Re the dreams, they may  be more related to what is being worked out under the surface then the medication itself.....
Member Comments (3)

by ledwards, Jan 20, 2004 12:00AM
I switched from Prozac to Zoloft many years ago and I was the opposite!  The Prozac "jitters" melted away after the Zoloft took effect.  I have taken Zoloft 13 years!   Ok, I am having some poop-out symptoms now, but my therapist is suggesting Luvox for the obcessive/compulsive symptoms I have that are similar to yours.

by susans, Feb 03, 2004 12:00AM
To: Magpie66
Hi Magpie66

Boy I sure have a lot in common with you. My need to keep the house spotless makes me feel extremely agitated and overwhelmed, I'm 50 and have a 7 year old and a 16 year old, work full time and when I try to clean he clutter that accumulates I get so anxious I wind up shuffling papers around. I took Zoloft for post partum depression and had insomnia for two weeks - was quite agitated. When the doctor added Adivan, I calmed down. Didn't gain wait on Zoloft. After feeling better, I was off meds for a year and then my son came down with OCD and I freaked. Since then I've been taking Xanax and tried several anti-depressants. I noticed weight gain began when taking Paxil. My doctor tried Wellbutrin for that, but no luck. I am now taking Lexapro, Xanax and Inderal, a beta blocker. I have gone from 125 lbs (a little thin for me) to 170 lbs in three years. Now I'm worried that the Inderal will increase the weight gain, but I'm having palpitations and lots of agitation so I felt I should give it a try. The Lexapro seems to have the fewest side effects, but I don't know how much it does for the anxiety.
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