Dear Brian,
I am not familiar with the mechanism and its side effects of SAMe. However, you failed to mention how long you were taking
EffexorEffexor
Effexor xr and how long you had phased yourself from
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Effexor xr. It is recommended that you are tapered off slowly from the medications because of withdrawal symptoms like agitation.
Like your doctor, I would be very cautious taking any type of medications without adequate research studies that goes along with it. Just because when you experience symptoms like you do, there is only limited information available for clinicians and patients alike.
Like all medications, herbal medications are without any side effects.
Sincerely,
HFHS MD - RG