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Mental Health  (Expert Forum)
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Zoloft Dosage § Side Effects
Answered by
Roger Gould, M.D. - Mental Health, Wellness
Questions posted in the Mental Health forum are being answered by Dr. Roger L. Gould, author of the Mastering Stress and Depression program and affiliated with the UCLA. Department of Psychiatry. Topics covered include anger, attention deficit disorder (ADD) , bipolar disorder , dementia , electroconvulsive therapy (ECT) , learning disabilities, memory, obsessive compulsive disorder (OCD) , panic , personality disorders, phobias , post-traumatic stress disorder (PTSD) , schizophrenia , stress , transitions, and work problems.

Zoloft Dosage § Side Effects

by Treehugger, Jan 24, 2005 12:00AM
I am 43 and have been struggling with general anxiety and mood swings my doctor feels is caused by perimenopause.  No prior history of anxiety or mood disorder.  I tried hormone replacement and CBT but the anxiety is still bad.  So about 2.5 weeks ago I started zoloft at 25 mg.  The zoloft lifted my mood and energy level but as the first week progressed I developed worsening tremors and internal shaking.  I dropped the Zoloft to 12.5 mg to see if it would help.  The very next day the tremors and shaking stopped.  Will the zoloft be effective at all at the 12.5 mg dose or do I need to switch to another medication.  Or should I try to add more zoloft a little at a time to increase the dose.  I was told that to control anxiety the dose needs to be at 100 mg.

Note:  I tried Buspar and Klonopin - but had bad side effects.

by Roger Gould, M.D., Jan 26, 2005 12:00AM
I don't believe that there is any set dose for Zoloft to be effective...some people are very sensitive and get what they need from a small dose...I would stay at 12.5 and then taper up but stay as low as possible.
Member Comments (3)

by Treehugger, Jan 26, 2005 12:00AM
Thanks so much.  Last night I tried going up to 18.75 mg and had tremors again this morning.  So 12.5 mg seems to be as high as I can go!
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