I hope others who have had the direct experience will respond, but the general guidelines are it seems to take two to three weeks of gradually coming back to yourself. What you have to be careful of is observing yourself too closely for when you do you tend to interpret the
normalNormal saline flush fluctuations as symptoms when in fact they are not symptoms, but rapidly changing states of mind that gradually become more integrated and less discrete.
-a feeling of slight pressure on my brain, as if there is sandpaper there
-my sleep cycle has been disrupted
-emotional blunting--can't feel any emotions except anxiety
alex
I have been on Zyprexa for five years, since I was almost 16. I gained a lot of weight, but it was very good because I was anorexic before and I finally had to accept a normal female body (taking zyprexa made me SO hungry that I finally realized I can't live without food anymore. I had reached that stage in Anorexia where the literal meaning of the word applied: I didn't feel any hunger anymore. I became kind of inhuman. When I became hungry again, my stomach actually felt like recovering! and I had the mental/emotional ability to do so, and to handle the feeling of "betraying myself" and identifying it as false. In my case it WAS the eating that gained me the pounds, not just ingesting the pill...I think that many people blame the pill without realizing that those times when we feel like eating the cupboards clean (and we do just that) is the reason for the weight gain...but then, it's such a powerful drug, it might actually mess with the thyroid? I don't know). That side-effect, with the combination of what it's supposed to do (lessen psychosis/delusions/anxiety), allowed me to calm down, come back to myself (for the first time!) and function. It DID take a while to get used to (a number of months for full-effect). Now, the very bad thing that I've done all throughout my years on Zyprexa was to decide to not take it anymore, on a whim. My mentality was: "okay, okay, now that I've acquired this wisdom about myself through the drug...I think that's enough, that's all I need to fly in this life...so...goodbye, Zyprexa!" And I was off, cold turkey. I would say I've done that about...6 times. But I always go back, because of the withdrawal+the realization that it has something in it that I NEED to function. Everytime I get off of it, I become a different person who is not someone I want to be. I recently got off for close to 2 months...until I got so sick I felt I was dying, I couldn't even function at work, it was embarrassing, I finally was shivering so bad and feeling hot-flashes+chills and dizziness and everything juuust-fffelllt-weeeiirrrd....I couldn't understand simple things, I was exhausted but I couldn't sleep, my heart was racing, my back hurt, I felt my chest was caving in and I couldn't breathe...and all my anxiety returned and I just went under so fast (felt like I did before I ever went on the med...but worse). Finally, I went into the bathroom and needed to vomit (I don't vomit easily, so it was the pinacle of unwellness for me) and then I decided I couldn't take it anymore so I nibbled off half a Zyprexa (2.5 for me) and within 5 minutes I stopped feeling so cold, and I was able to calm down, and my thoughts made sense again. It was interesting because my brothers and mom saw me shaking and gasping on the couch and not being okay with the slightest noise (I was convinced that everyone was trying to annoy me...I seriously turned into a mega-***** and was very interpersonally paranoid)then I went into my room...and fifteen minutes later I came out and completely normal again. Needless to say, they noticed the difference and were glad to have me back again. I felt shaky...but I'd just put myself through a lot of unnecessary pain for the past two months. I wanted to find out if I still needed it, and if I was well enough on my own natural chemical balance...and I found out that I was not. It's nothing shameful to need a little (perscribed) pill for our well-being. Zyprexa may not be the right med for everyone...but I think that anyone who takes any anti-psychotic medication and knows he/she needs (down in your heart) then stay on it... Zyprexa is to me as Coumadin is to my friend Mohammad who requires it for his heart. And he told me that himself. I agree 100%. I won't waste anymore time with "checking to see if I still need it." It wastes time I don't have. When I'm on Zyprexa, I'm sharp, and insightful, patient, tolerant, happy and calm. Any genious I have in me (and we all have it) shines through and I can think. When I'm not on Zyprexa, my mind feels blank but buzzing with unwanted thoughts and confusion and exhaustion from being strung along by something out of my control...exhaustion from not even being productive, rather trying to hold onto sanity but always losing. And always being so defensive and aggitated, frantically unhappy and outwardly hysterical about anything I felt. It has been hard for me to accept that I need this medication, as I'm a proud person. But I fell into the care of the finest and most open-minded psychiatrist in Portland, who could really know me from the first session I had with him and could see the true Cheryl getting through during my worst times. He had faith in me. And I have more faith in his judgement now than I did when I was seeing him. I'm glad of every choice he made for me when I couldn't make it for myself. He had a vision of a healthy, brilliant and unique person, and his devotion to help me find myself as that person was amazing. Now I make all my own choices and make wonderful choices, except when I decide to get off Zyprexa. Exactly why I do it is a mystery. But, for everything I love and dream of and desire to be (me), I need to never do it again.
Love, Cheryl
I was pretty dependent on zyprexa to function... I went back to my psych, and manipulated him into giving me more zyprexa daily.. I felt I needed it, to sedate my day away. At that point, that's all I wanted. I was huge, and that much zyprexa had taken away all emotions, and feelings. So, He upped it to 20 mg's daily. To make a long story short, by the time I had had enough, I was taking 30-35 mg's daily, sleeping for 15 hours a day, and weighed 225lbs. toghether, we deciede it was time to get off zyperxa. I went through rapid detox, experiencing muscle aches, stomach cramps, headaches, severe anxiety, and rebound mania. I have had protracted insomnia as well. I still can't sleep as well 4 months later. Those who say one can't go through zyprexa w/d, is mistaken, including my doc. I'm losing the weight. I'm on new meds, and I'm encouraged...
i feel like i'm going thru the worst ... i was on 5 mg zyprexa and 75 mg avanza. i felt like it wasn't doing anything for my head space [still manically depressed then thru the roof high] and i was just gaining weight like crazy. i put on 15 kilos in 2 months. the weight gain is making me skip meals [i haven't eaten anything in 2 days]. i can't sleep at night - i always wake up after a couple of hours of sleep with crazy, crazy intense dreams. i have now a really fast heart beat and my gp has prescribed blood pressure medicine. i felt that nothing my doctor was prescribing me was helping so i stopped taking everything. i just feel like i'm going outside of my head and sanity. it's good to hear that others have had similiar probs with the medication ... but our drs don't seem to be listening.
Has anyone been thru those kinds of withdrawal symptoms? How long did it last?
I am only on my eleventh day of withdrawal from zyprexa, and like you described, I am suffering severe nausea. I'm very lucky that I haven't actually vomited, but I'm not eating much.
I had an anti-emetic called metaclopramide in my medicine cabinet, so I tried that, but it didn't work.
My family doctor has now told me that certain neurons in my brain that regulate appetite and nausea are absent as a result of 4 years of zyprexa. He told me that they will rebuild, but that it will take time. He suggested that two months sounds like a reasonable timeframe for this. He insisted that this would definitely get better. I hope he is right and I hope that this gives you hope too.
He also told me that typical anti-emetics will not work for this, because it is not a stomach problem, it is a problem with brain chemistry. He told me that the only thing that would stop this nausea would be a traditional anti-psychotic drug like mellaril. I have opted not to go for this, as I am already suffering from TD due to zyprexa and do not want to make it worse.
My doctor compared this type of intense nausea/vomiting to what people coming off drugs like cocaine go through (I think that's the drug he mentioned anyway). Those people would take something like mellaril to calm it. Apparently diazepam will also calm it slightly for some people, but I have tried this and it hasn't been of much help, I'm sad to say :(
I'm going to stick it out, but it is very hard. I have to say that my family doctor (the one who has given me all this info) seems to understand this a lot better than my psychiatrist who prescribed me the medication. I'll leave it at that!
~ Ouida
Your doctor sounds like a knowledgeable person. I have been to several doctors for Zyprexa withdrawal and they all say there is no such thing. However, I know otherwise. I am now into my 8th week and it is getting better, but it has been rough. I will never take that stuff again.
There seems to be so little on zyprexa withdrawal on the Web. That might be because it's a comparatively new drug, unlike say diazepam where the withdrawal info is probably everywhere!
Could your doctor see a psychologist to assess whether she genuinely has bipolar disorder? I'm no expert on this, but a questionnaire from a family doctor might not be the conclusive proof you need. Also, there are also other drugs for bipolar: anti-convulsants such as carbamazepine and also lithium. Your wife would have other drug options.
Don't let your doctor talk you into this. Your wife has rights, it's her brain and her health, and it's her right not to have it damaged. It's a comparatively new drug, and a lot of doctors still don't fully understand these withdrawals and how bad they can be. I think a lot still don't realise the effects of this drug on some people.
About the nausea:
My family doctor has now prescribed me a drug called "Domperidone" (aka, Motilium) for the nausea. Thank god, it seems to be working but although it gets rid of the nausea, it doesn't seem to actually bring my appetite back.
It's impossible to say how long the withdrawals will last. Some of it might depend on how long your wife was on the drug. Can you find a different doctor, who might help prescribe something for the withdrawals? (eg. a sleeping drug for the short-term, some form of anti-nausea medication? Some anti-nausea meds won't work on this and the ones that normally do are normally other anti-psychotics. Domperidone seems to be a lot less risky than those for dystonic reactions.)
She visited with her family physician yesterday and he changed her meds. At times I'm wondering if he is just going through a medical book trying to figure out what might work. He now prescribed Risperdal (.5mg) as well as cutting her Effexor ER in half and suggested that she get off of the Buspar because it "doesn't work". Fortunately he has referred her to a psychiatrist. She saw one about ten years ago over a number of sessions and apparently he gave her a lot of advice and was quite helpful. Then she saw another one about four years ago who was simply into pushing Prozac. Given her/my concerns about the family physician's changing of her meds when everything seemed to be going well for her and his responses to her questions and concerns of Zyprexa we see this as a good move. Oh, and his response when she expressed her fears of the Zyprexa withdrawl that she was going through was to say that there are no withdrawl symptons associated with Zyprexa. Great advice!
Thank you again for your comments.
And has anyone any thoughts on Risperdal? Have found little information about it so far although it does appear to be in the same family as Zyprexa which does raise a red flag for us.
Tell your wife to stay far away from Risperdal. It is in the same family as zyprexa and carries the same problems. I think your wife is better off staying away from psychiatric drugs in general; everybody is. These doctors get nice perks from the drug companies for pushing these toxins.
I have a question for anybody out there--after my insomnia bout, I went back on the drug and have been tapering off more slowly, but what's happened is my sleep has gotten really weird. I fall asleep as if someone flicked a switch in my brain, and I have no dreams. Then when I wake up, it's as if another switch was flicked. I am instantly wide awake. And I never feel tired or that groggy feeling you get when you're first falling asleep or when you first wake up. It is very unpleasant. Can anyone else relate?
To anyone who reads this--STAY OFF ZYPREXA. IT IS BAD NEWS.
Some people have found relief by going back on it and then tapering the dosage down. I just want to be through with it for good.
Thanks for letting me whine to you. It helps to know there are those out there that have gone through or are going through this.
Jo
I've always, I believe and from research have had depression episodes or problems with depression. But I don't ever remember having had slightly manic episodes. Not the extreme kind, just feeling very euphoric and like everything is beautiful. So my question is.
Has anyone when they started taking Zyprexa had problems like these come up stronger then before? I know Zyprexa is supposed to treat stuff like this, I was just wondering if Zyprexa could be part of my problem as well?
I'm predisposed to have manic depression or a slight case of it as my mum's mother had it. But I don't remember it being this strong before. So yeah, I just wondered if Zyprexa was making me more bipolar rather then helping.