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1218873 tn?1300094816
Duloxetine ???
Does anyone take this?

I went to see my consultant, who deals with my medication. I had expected him to up my dose of Lyrica from 400mg a day to 600mg a day, as I still have a lot of neuropathic pain. But instead he stopped my amitriptyline which I take 50mg at night and changed to 60mg Duloxetine at night.

I gather it is an anti depression tablet also used for neuropathic pain in diabetic's I am not Diabetic.

So I wonder what peoples opinions were?
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1453990 tn?1329235026
It is the same drug as Cymbalta.  It is an SNRI and I think there are a few people on the forum that use this for neuropathic pain.  Most of these medications work for neuropathic MS pain in the same way the work for the pain of diabetic neuropathy.  They alter the conduction thresholds of ion channels in the nervous systems.  The same is true of several anti-seizure medications like Tegretol and Gabapentin.

Bob
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First thing to note, Unfortunately smoking does affects the amount of duloxetine in your system and blood stream meaning that you will loose between 40 - 50% of the duloxetine dose you take. It is not uncommon for people to have their duloxetine prescription increased if they smoke. Unfortunately it is not uncommon if you miss a dose to be experiencing these problems if your on a high dose, my patients even at a dose of 30mg do experience brain zaps, nausea and vomiting even with just one day missed. This is why duloxetine should be withdrawn extremely slowly and only under professional help. I always recommend being on duloxetine for a solid 12 months at the right dose for you before you even consider reducing or think about coming off the drug, kind regards
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1530171 tn?1448133193
This thread is almost 6.5 years old.
You need to look at the dates of the posts.
Nevertheless, you mention Duloxetine withdrawal and effects, however the drug discontinued was  Amitriptyline.
Just to set the record straight.
Cheers,
Niko
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