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Experience with Cymbalta or Lyrica?
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Experience with Cymbalta or Lyrica?

I'm wondering if any of you have experience with Cymbalta or Lyrica....

Why was it prescribed - what symptom was it supposed to work for?

how long did it take for it to begin working with your pain?

Did you have any problems with side effects?

Anything else you can add?

Thanks for your input,
Lulu
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21 Comments Post a Comment
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867787_tn?1318939830
I was prescibed Cymbalta for nerve pain (I think the Dr. was thinking fibromyalgia to be honest) & it did help some with the pain but not with the spasms or my other mobility issues or bowel & bladder sx but I guess it wasn't supposed to help with those. I took it for a little over a month, I was told it takes a month to get in your system properly. The side effects were: nervousness & felt shaky. it made my insomnia way worse even though I took it 1st thing in the morning. I personally didn't find it beneficial but I know others here have. I took Lyrica for 3 weeks & wanted to sleep all the time but, I probably didn't give it a fair chance. I was thinking of trying the Lyrica again due to my insomnia issues. I hope this helps some!! Take care!!
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648910_tn?1290666683
Not Cymbalta but I take Lyrica.  

Rxd for neuropathy, both the pain and the paresthesias.

i started at 50 mg 3x daily then it was increased to 100mg 3x daily.

I had no problems with the 50 mg dosage, no sleepiness, feeling of being high etc.  When it was raised to 100mg 3x I had to titrate up.  I was stoned for lack of a better word.  So I did the 100 at bedtime, 50 for the other two.  Then I added the one in afternoon after I had accomplished all driving etc.  Finally the last and I am having no side effects.

Yes it lowers the pain etc.  It is like you don't know how much until you are not taking it.  I tried that and I don't recommend it to anyone...lol

My weight stabilized for 2 months.  The third I had gained another 2 pounds.  How much is the weight and how much is all the sitting driving to dr appts and waiting to see the doc I don't know.

I do know on the neurontin I was gaining every month. .. 33 ils in 14 months :0(

hope this helps terry
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572651_tn?1333939396
Thanks for the responses - this isn't for me, but for another forum member who is trying to weigh her options.

yes, this does help.
L
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I have taken Cymbalta for over a year.  It was prescribed for Depression.  It has really helped my depression.  I have noticed it helps some of the minor pains I have.  I still have the major spasms, etc.  

I took Lyrica at one time.  It didn't help at all with the pin prickling sensations at all.  As a matter of fact, I think it made them worse.  I was working at the time and couldn't hardly function.  I was always sleepy with it and walked around like a zombie.  Lyrica works for some people and I was not one of the lucky ones.

Hope this helps
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279234_tn?1363108849
I was prescribed Lyrica to help with my muscle pain. I have a lot of pain from the spasms/spasticity that I get. They tried me out on a low dose at first. It didn't seem to do anything. They upped the dose...and still nothing. I didn't have much luck with Lyrica. I gained weight on it as well.

They tried me on Cymbalta for pain as well. I was started on a low dose at first. I noticed within the first day I was on the medication I felt nauseated. I felt like I was going to get sick..but never actually did. I felt like this all day!. When I stopped the Cymbalta on the weekend, the nausea went away. I just couldn't tolerate the medication even at a low dose.

I'm currently on Neurotin for pain. It seems to work for me and at least take the edge off.
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620048_tn?1358021835
I have been taking it for quite awhile and it was prescribed for depression and I was told it will help some with pain.  

You know with this memory I can't remember exactly what it did, it did help with depression and pain and i can't remember what else but whatever it did for me, i have been raving about it for a long time.

Before my diagnosis they dubled it and I felt it almost right away...

hugs, meg
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Avatar_f_tn
I googled it. Cymbalta is considered an antidepressent (SSNRI - selective serotonin and norepinephrine reuptake inhibitor). It can be used to treat depression, anxiety, chronic pain (like fibromyalgia)  and pain caused by nerve damage (like diabetic neuropathy). Hope this helps.

milwrite


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572651_tn?1333939396
Thanks everyone.... so often doctors are using drugs for off label uses and it helps to hear others' experiences.

my best,
Lulu
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562511_tn?1285907760
I tried Lyrica for pain.  Made me sooooo sleepy and didn't help the fibro-type pain.

My neuro has suggested a trial of Cymbalta.  Haven't done that yet.

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Good Morning, LOL, it's 12:30 am. I am currently taking Cymbalta for nerve pain from fibro,spinal problems, and leg neuropathy. I'm not sure if it's helping, been on it since June. I have been having severe dry eyes this summer, which is listed as a side effect. I see my PCP  next Wed, am going to ask about discontinuing it, have to taper off.  I have tried Lyrica twice. For me, it was wonderful. It started working in 2-3 days. I could do activities I hadn't done in several years. Unfortunatly, I also gained 20lbs in a month. Can''t have that, being type 2 diabetic, so went off it. I tried again about a year later hoping to be able to control the weight, but no luck, so am back on Neurontin. Works almost as well for me, without the weight gain. Lyrica makes you crave carbs.  Hope this helps.

Maggie
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335728_tn?1331418012
Thought this might be of some interest:

Two drugs better than one for chronic pain: study
Updated Tue. Sep. 29 2009 10:36 PM ET

People who suffer from neuropathic pain often struggle in vain to find relief from the agony. Now, a new Canadian study suggests relief might be out there already, in the combination of two commonly-prescribed drugs.

Researchers from Queen's University in Kingston, Ont., have found that an anti-seizure drug and an antidepressant taken together is a more effective treatment than either of the medictions alone.

Neuropathic pain has been described as burning, stabbing, and unrelenting pain that can be felt everywhere. The chronic condition often follows nerve damage from diabetes, back injury, shingles infections and other causes.

Debbie Loder is among the one per cent of Canadians who suffer from chronic neuropathic pain. In her case, it was triggered by her type 2 diabetes and stopped her from ever getting a full night's sleep.

"There would be stabbing pains through the night," she remembers. "The longer I was laying down, the worse the pain."

While patients sometimes get pain relief from morphine and other of the strongest pain relievers, the Queen's team says a better option might come from combining the anti-seizure drug gabapentin and the antidepressant nortriptyline.

Dr. Ian Gilron, director of Clinical Pain Research for Queen's Departments of Anesthesiology, and Pharmacology & Toxicology and an anesthesiologist at Kingston General Hospital, found that not only do patients report pain relief, they also report better sleep - something not seen in morphine treatments.

"That's a very important issue for this group of patients, whose debilitating, unrelenting pain often interferes with normal sleep," Gilron said in a news release, announcing the study's findings which are published in The Lancet.

Each of the drugs has been recommended for neuropathic pain relief on their own. However, the drugs rarely reduce pain by more than 60 per cent and only about half of patients find they work at all, in part because the dosages have to be capped because they carry serious side effects at high doses.

But Gilron found that combining the two allowed more people to report relief. In his randomized controlled trial, he tried the combo on 56 patients with diabetic neuropathy or postherpetic neuralgia (the chronic pain from shingles). All the patients reported their daily pain as at least a 4 on a scale of 0 to 10.

There were three daily treatment plans: gabapentin, nortriptyline, or their combination. All patients got to try all three treatments over three 6-week periods. Overall, more people reported good pain relief when the drugs were combined:

•64 per cent reported moderate to complete relief with gabapentin
•75 per cent reported moderate to complete relief with nortriptyline
•81 per cent reported moderate to complete relief with the combination.

There were few side effects from the combination, though some complained of dry mouth.

Debbie Loder was one of those who got relief, and for her, that meant she could finally get some sleep.

"The combination of pills worked, very, very well," she reports.

Dr. Jane Aubin, Scientific Director of CIHR's Institute of Musculoskeletal Health and Arthritis, says the findings are an interesting and important result.

"Many chronic pain sufferers don't sleep well, and they get caught in a vicious cycle in which less sleep equals more pain. Dr. Gilron's work offers new hope to Canadians desperate to put an end to this debilitating situation," she said in a statement.

Doctors suspect the drug combination might also be used to treat other forms of chronic pain, from arthritis, back injuries, even pain from cancer therapy. Researchers are now planning more studies of other combinations of drugs that may ease pain better together, than they ever did on their own.
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335728_tn?1331418012
I have tried Lyrica and it was a ride I don't want to repeat but in all fairness my boneheaded Neuro overdosed me!  He prescribed 75mg 4 times a day!!!  I took it for two days and lost my ability to speak and caused me to have vertical double vision and it was the scariest experience I have ever had!

With that said, my hubby has been diagnosed with Spinal stenosis as there is a nerve being pinched by bone fragments in his spine and this gives him horrible pain.  His dr. advised him to try Gabapentin and it was useless to him.  So at an appointment that I went to with my hubby I asked the dr. about the possibility of trying Lyrica and he actually agreed!  He also added Cymbalta and the results are amazing!!  My hubby was in horrible pain and within a few days he noticed that the pain was dissipating and he was able to move again!  Now I had told my hubby that the Cymbalta is actually an antidepressant but it is working with the Lyrica to ease the pain and hubby of course had to ask the dr. why he had him on antidepressants.  The dr. replied that the Lyrica works better when combined with the Cymbalta and therefore he considers it a pain killer!

So that is my story in a nutshell and I hope I have been of some help here!

Lots of Hugs,
Rena
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335728_tn?1331418012
Oh yeah...hubby has had no side effects whatsoever so I think Lyrica is just something that has to be tried slowly and responsibly and for some it works...for other's such as Heather and myself...NO THANK YOU!!!  My new neuro has suggested that he might try it again but will ensure that I would take it gradually and he would have to be updated as to any side effects but we haven't come to that yet.  If it works for you I think it is a wonderful drug that offers so many a whole lot of relief!
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1279517_tn?1271208106
I do not have any of the symptoms above. I have agonizing back pain. My wife is a nurse for a staffing agency so she sees alot of of different cases. She came across this combo (lyrica/cymbalta) for the fibro patients and had heard that it was a good pain reliever.

Two years ago I was prescribed 3 Somas a day (max dose), and three (as needed) darvacet. That helped for about a month... then it turned into two darvacets at a time... then sometimes three or one every other hour. Told the doc and she changed me to hydrocodone/loratabs. We started out at the 7/500 I think... and like the darvacet helped at first but slowly lost their "potency". I have been taking the 10/500 Loratabs now for several months.... I am prescribed to only take 3 a day, but I take 6 a day... and that's only because I try to stretch them as far as I can. She will only prescribe me 90 at a time and that is supposed to last a month... again, they only last two weeks... so I go through spells where I am "dealing with the pain" for two weeks... and then two weeks of agony.

The Somas are perfect... sometimes I take two at a time, but typically the three a day for muscle relaxation is enough. The thing is that, neiter the soma nor the loratab work well unless they are taken together. I can eat 3-4 loratabs by themselves like candy and they simply don't do ANYthing for me. My sister is the same way. I have an older brother though that takes one and ends up getting "high" for a couple hours. Why would they not effect me? It's like I'm immune to narcs unless I take a whole lot of them and combine them with others. Even in my partying days... drinking would cost alot of money because I have such a high tolerance.

As a teen I tried smoking pot recreationaly.... and had fun for literally a couple weeks, but it just wasn't my thing. Made me nervous and hunrgy. Sometimes I would even hallucenate... I don't like hallucenating. Scary. Even when you expect it... it's not fun. Recently, I got ahold of an adult friend that still smokes pot recreationaly. He was really suprised that I asked him to come by because I am so "anti-drug" now that I have started a career and family. Anyways, the pain was so bad that I asked him to get me "high". I smoked a couple hits and it did nothing for me. I got a buzz off of it, but I really didn't like it and the whole purpose was to get rid of the pain... it did not do so.

I only want to get rid of the pain.

I brought up the combo (lryica/cymbalta) to my doc and she said it'd be worth a shot. Since I have always suffered with depression, I thought that maybe it would be a good thing to try for dual purposes. I have never really taken anything for the depression. I honestly don't like take meds at all... not even tylenol for pain.

I have been honest with her about being worried about addiction.... my father died at 48 because of his drug use. I have two perfect baby girls and I want to watch them grow... so I am very worried about getting hooked on something. That's why I resorted to trying pot again... I'd rather be addicted to the plant than all of these crazy chemicals that are eating away at my liver.... I mean, have you ever seen a liver patient!? Not something I want to go through.... but nothing works. These Loratabs aren't working anymore... I can't keep taking them like I am. The next step is either Morphine or Oxeycontons... that just scares the hell out of me.

Does anyone have any experience with back pain and this combo??? I have two ruptured discs, and several that are protruding. My tail bone is crushed in the opposite direction. No good reason for any of it... they think it is hereditary to an extent, but that at some point, I must have been in some kind of accident. I am 26 years old and following my dad's path almost to the tee... he is dead. Died at 48 years old in 2008. I don't want to follow suit... I'm trying to be responsible... I have a 3yr old and a 2yr old.... I work in radio... I own a house and I restore old cars. The last thing I want is a drug addiction.

Any help!?
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Avatar_f_tn
I am trying out Cymbalta now. I have fibromyalgia, depression and insomnia. I am using it to replace another medicine in the hopes that this will address some of the other issues, as well, that I have with fibro. I've been taking it for more than a month now. My side affect is heartburn. I take it around 18:00. It affects the depression a bit differently than my last med, so I haven't decided quite yet. I'm not having the extreme lows and I'm having what are probably normal highs in my moods. The last med took away that and I was not usually depressed but never really ecstatic about anything either. The pain hasn't stopped but it is manageable most of the time. I'm adding traZodone in the evening to help with the insomnia.  Hopes this helps a bit!
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Avatar_f_tn
In 2005, before being diagnosed with MS, but being tested for it, one Dr. prescribed LYRICA.  It made my tingling and pin prickly sensations much worse.  Needless to say, He took me off of it.

I have had problems with depression since early 1990's and have been on various anti depressants.  Imyprimine which my PCP prescribed for the depression, anxiety attacks.  Later, my depression and panic attacks disappeared for a while.  In 1997, I began having symptoms of the pin prickling, numbness, etc.  Once again, this same PCP put me back on the Imyprimine for the sensations.

As time went by, I was put on paxil for the depression.  I took wellbutrin for a while and that was horrible.  In 2008, I finally wound up on Cymbalta and by accident, I realized it was helping with my fibromyalgia pain.  I've been on Cymbalta ever since.  
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2015036_tn?1333001388
I've never taken it.  We talked about it though...  I was told that it basically functions the same way as Neurontin/Gabapentin, that the medications were related in some way.
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5112396_tn?1378021583
I took duloxitine (Cymbalta) for depression, not pain. I took it for about 6 months, as directed (it was titrated in that time). Like the potpourri of pill, capsule, liquid, and chewable MAOIs, SSRIs, Tricyclics, tetracyclics, and SNRIs I've taken for the same reason and to the same spec (as directed, for extended time, trying different dosages as instructed)...

it did squat.

Depressive episodes seem to come as they like and leave as they like with no rhyme or reason, whether I'm on medication or not. What I've learned through the years is how best to batten down the hatches and ride out the storm, knowing it will pass. (And no, I never expected them to be 'happy pills', but I don't think anticipating some sort of mood stabilisation was an unwarranted expectation.)
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1831849_tn?1383231992
Neuropathic pain responds differently in all of us. They are not sure why antidepressants and or anticonvulsants work in fighting neuropathic pain, but they seem to.

Often they are used in combination.I currently take 300mg/day of Lyrica (pregabalin) and 75mg/day of Elavil (amitriptilyne). Lyrica is very similar to Neurontin (gabapentin) which is an anticonvulsant. Elavil is an antidepressant.

It can take time to dial in the right combination, or dose of a single med. These meds need to be titrated and the process requires a little patience.

Kyle
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6881121_tn?1392834388
After being on a slew of SSRIs for depression over a couple of years, one of my daughter's MS team, a psychiatrist, suggested we try Cymbalta, because it often also helps with annoying skin sensations and nerve pain. It has been working pretty well for my daughter.
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667078_tn?1316004535
My mother cut her hand off and they put her on stelazine and amityriptiline for the constant pain.

Alex
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