MS in the news: Disease Diagnosis In Just 15 Minutes

Disease Diagnosis In Just 15 Minutes
01 Oct 2008  

www  medicalnewstoday  com /articles/123781  .php


Testing for diseases such as cancer and multiple sclerosis could soon be as simple as using a pregnancy testing kit.

A team led by scientists at the University of Leeds has developed a biosensor technology that uses antibodies to detect biomarkers - molecules in the human body which are often a marker for disease - much faster than current testing methods.

The technology could be used in doctors' surgeries for more accurate referral to consultants, and in hospitals for rapid diagnosis. Tests have shown that the biosensors can detect a wide range of analytes (substances being measured), including biomarkers present in prostate and ovarian cancer, stroke, multiple sclerosis, heart disease and fungal infections. The team also believes that the biosensors are versatile enough to test for diseases such as tuberculosis and HIV.

The technology was developed through a European collaboration of researchers and commercial partners in a 2.7 million Euro project called ELISHA. It features new techniques for attaching antibodies to innovative surfaces, and novel electronic measurement methods that need no reagents or labels.

ELISHA was co-ordinated by Dr Paul Millner from the Faculty of Biological Sciences at the University of Leeds, and managed by colleague Dr Tim Gibson. Says Dr Millner: "We believe this to be the next generation diagnostic testing. We can now detect almost any analyte faster, cheaper and more easily than the current accepted testing methodology."

Currently blood and urine are tested for disease markers using a method called ELISA (Enzyme Linked Immunosorbant Assay). Developed in the 1970s, the process takes an average of two hours to complete, is costly and can only be performed by highly trained staff.

The Leeds team are confident their new technology - which provides results in 15 minutes or less - could be developed into a small device the size of a mobile phone into which different sensor chips could be inserted, depending on the disease being tested for.

"We've designed simple instrumentation to make the biosensors easy to use and understand," says Dr Millner. "They'll work in a format similar to the glucose biosensor testing kits that diabetics currently use."

Professor Séamus Higson, Dean of the Faculty of Medicine and Biosciences, Cranfield Health, and one of the partners within the ELISHA programme, says: "The speed of response this technology offers will be of great benefit to early diagnosis and treatment of many diseases, and will permit testing in de-localised environments such as GP's surgeries."

A spinout company - ELISHA Systems Ltd - has been set up by Dr Gibson, commercial partners Uniscan Instruments Ltd and Technology Translators Ltd to bring the technology to market.

Says Dr Gibson: "The analytes used in our research only scratch the surface of the potential applications. We've also shown that it can be used in environmental applications, for example to test for herbicides or pesticides in water and antibiotics in milk."

[doni54]

WOW, wouldn't that be wonderful!?!

doni

[Wobbly]

gee...let this happen now...if only eh...
thanks for the update...if only

wobbly
LL

[mary_kay]

Just think! Early dx on many diseases...even MS.  Amazing.  I could avoid that lumbar puncture...  MK

[Rena705]

Thanks for the information...I wonder if it would be beneficial for all the members to print this document off and send it to their neuros anonymously...at least it would be informative for some that are living in the 9 lesion dark ages! hehe

Rena

[Lulu54]

Sometimes it boggles my mind, not that boggling my mind is a complicated feat, to look at the advances that have been made in medicine.  What wasn't even dreamed about 20 years ago is now reality in so many fields.  This next proposed step sounds wonderful - imagine minimal testing to get a diagnosis in a hurry!

Here's hoping,
Lulu

[OperaMBA]

Yes, but what they neglected to say was WHICH 15 minutes it would be!

Where is Andy Warhol when you need him??????

Richard
OperaMBA

[Salamander2]

Give up my 15 minutes of fame for a 15 minute diagnosis?  You betcha.
Sally

[Momzilla]

Richard --

I like the way you think, man.

Zil*

[Quixotic1]

Everyone needs to realize that this technology is still likely years away.  Once they have a test it is at least a couple years to FDA approval.

The second problem is that as of yet there are no biomarkers for MS.  None have yet been discovered that are distinctly and uniquely found in MS.  The search for biomarkers, as we have talked about before, is one of the biggest pushes in MS research going on.  Many seem promising, but the holy grail has yet to be found.

So, while this "would be" a great thing, there are still some significant hurdles.  I can be such a downer, can't I?

Q :((  

[Momzilla]

I wondered if there were biomarkers.  Presumably, the testing would be possible already in hospitals, then, right?  Dagnabbit, Quix, you do know you to throw water on a fire.

Ya doctor, ya.

Z*