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Other Rebif users had trouble with aspirin?!?!?

I've been taking Rebif since my Dx in March with no problems until last night! I took aspirin before my shot instead of my usual ibuprofen and have never felt so horrible. When they say "fllu-like" symptoms that's the understatement of the millenium!!!

I shivered so hard I thought I was going to crack my teeth. I could barely hold a cup of water from the shivering and shaking to take some ibuprofen. Trust me that I will avoid aspirin at all costs in the future when taking my shots. I still feel kind of icky today but am functioning.

Anybody else experience this???

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Avatar universal
I did some research on a more in-depth medical aspect and find no bad interaction with Rebif and Aspirin.  In fact the swedish.org clearing shows in its rebif instructions that one can take up to 650mg of aspirin every 6 hours for relief from flu like symptoms.

Perhaps you just got a weird reaction this time.  I sometimes get a bad one from my Tysabri, for example, my last one was accompanied by a headache that lasted almost 24 hrs and then went away.  But all others had been ok.

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2078115 tn?1333926565
Hi Richarme! I've been on Refbif since mid-April

While I've never taken Asprin, what you've described is nearly identical to what I experience when I forget to take anything with my injection all together (I usually take Advil as well).

Often people experience a different response to different medications. It could just be that for one reason or another, while not the *cause*, Asprin is useless for mitigating our specific post-injection side effects. In other words, you might as well be taking nothing when you take an Asprin. My MS nurse suggested that Tylenol is the most effective NSAID in preventing the ickies, but Ibuprofen works almost as well [?].
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