anyone had 3 x day IV meth/predisolone not work

Hi All

Just curious to how many of you dx and not dx - that have had the 3 x day steroids and they not worked..  
my cognitive thinkin seems to have improved but no change in numbness pins needles left arm..  its been 3 weeks now since i had IV,s

jan xxx

[Quixotic1]

Early after my diagnosis I had three 3-day courses of steroids and none of them did squat.  My neuro feels that although he thinks I am RRMS, the majority of my active disease is in direct neuronal death rather than immuno-inflammation.  The steroids are only active on the inflammatory part.

The steroids don't always help.  If they are going to you will see the improvement start within two weeks.  

Quix

[nickismydog]

I had 3 days of outpatient treatment with solumedrol. No change. It has been two weeks now. I have sensory loss from my waist down.

[Sparkysarah]

I had 4 days of oral steroids and did not notice a great deal of change even after 2 weeks, and still felt very fatigued (whereas most people report a surge of energy). I asked if there was any difference between oral and IV steroids and he said usually not although IV obviously hits the blood stream faster. He said maybe next time I shd try IV.

Love Sarah x

[janbubears]

Thanx guys

nickismydog are you dx ms or not xxx

im still confused re outcome of steroids  xxx
jan x

[Quixotic1]

Early after my diagnosis I had three 3-day courses of steroids and none of them did squat.  My neuro feels that although he thinks I am RRMS, the majority of my active disease is in direct neuronal death rather than immuno-inflammation.  The steroids are only active on the inflammatory part.

The steroids don't always help.  If they are going to you will see the improvement start within two weeks.  

Quix

[janbubears]

hi quix thank you

im gathering that direct neuronal death means permanent nerve damage???

do the steroids always work on any kind of inflammation.   If i had arnold chiari or syringomeyelia - would steroids be used for that xxx

sorry for the loads questions only a friend ive made on here has been dx with chiari she thought she had ms xxx but her sx were similar to mine

jan xxx

[Quixotic1]

No, syringomyelia and Chiari malformations cause mechanical problems from pressure or pulling on the brain and nerves.  I would not think that steroids would be useful.   There are often used after corrective surgery on the brain or cord to reduc post-op swelling, tho.

Quix

[mayperl]

Hi Jan -

Just a few words on my personal experience with solu-medrol.  I was on a 5-day infusion for loss of vision.  Took a month afterward before I started to see results, but who knows if it was b/c the steroids or natural wane?...

Next time I had the 5-day infusion was in March for heat band and down my leg.  Felt better after 2 weeks.

*shrug*

[mayperl]

Not a fan of steroids tho.  Would rather go without next time.  The headaches from infusion are painful and last for days.

[Sumanadevii]

My experience on solu-medrol is what Quix said.  It is inflammation for me and it works wonders.  Before I had taken it, I could not have explained the numbing.  The swelling prevented me from feeling anything above my chest level.  Day three of first infusion I knew what numbing was!  It felt like Novocain had been shot in my bottom, thighs, legs and feet.

Also on day three of the first set, I was able to put less weight on my poor husband getting up and down steps.  I only needed him to keep me steady.

I don't like not being able to sleep on the infusions but it has been worth it.  The second set I finished up today.  It didn't do as much but then I was doing much worse this time..lol...Go figure.

[4084Tachi]

     Had a case of optic neuritis, no pain nothing but blurred vision with a little floating dot in focus and lack of color in right eye.  Normal eye doctor sent me for emergency MRI with dye.  Radiologist found no difference between that MRI and one from seven years earlier.  Still had a little white spot in the same place but not in brain area known for vision which was thought to be echo from migraines.
     Went to neuro-optho who placed me on three days of solu-medrol (IV) and three weeks of oral steroids (3x day).  A year later and still no change in optic neuritis.
     However, I wanted to know why.  Got answer through MS neuro who followed through on tests and uncovered MS.  Second symptom showed up two weeks prior to the anniversary of the optic neuritis, pins and needles in feet.  Now on Neurotin to help with parathesia.  Slows me down a little but it's helping.