In my case, I had One MRI lesion and One clinical lesion (Optic Neuritis - pointing to demyelination of CN2 without MRI evidence) and then I developed 4 more MRI lesions and an additional clinical lesion (Trigeminal Neuralgia - pointing to demyelination of CN5 without MRI evidence.) Two exacerbations separated by more than 30 day in two different areas (ON was cerebral and TN is midbrain) demonstrates dissemination in space and dissemination in time.
Some doctors are comfortable with this type of diagnosis, while others are (shall we say) more difficult.
Bob
Just curious,,, would that mean like, hyperreflexia, optic nerve damage, one sided tremor in hand, and overshooting or undershooting a target. Are those, Clinical lesions?
Thanks, pam
Bob will probably be back to clarify but I think by "clinical lesion" he means clinical evidence (visible to the doctor during an exam) that a lesion exists even though it doesn't show up on the MRI.
Mary
I am no expert, but if I remember correctly, it's the location and the "time" and "space" requirement. Atleast one old and one new lesion shown on MRI along with history showing more than one flare.
What's the difference between "clinical lesions" and "MRI lesions"?
Well, you need two "clinical lesions" and no MRI lesions (hyperintensities) for a diagnosis of MS. One clinical lesion and one MRI lesion would be CIS. Most of the time, it usually doesn't work out that way.
Bob
Hi,
its not just number of lesions, it's location, location . location and size and shape.
Visit our health pages and this link may be helpful
http://www.sciencedaily.com/releases/2011/03/110309162117.htm
take care
Johnniebear