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MS?
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MS?

Hi, I am a 41 year old female with severe muscle cramps in calve muscles and spacticity in feet. I also have been experiencing fasciculations in lower legs and less common in abdomen and upper torso. I have had slight weakness in left arm which is also intermittent (every four to six months).
I have had two MRI's, the recent one with contrast, which both showed no evidence of demyelination or ALS.  My blood results are normal also, although I'm awaiting more blood results regarding Vit D levels. I had a clinical evaluation about 7 months ago which I passed as I had no symptoms at the time. My concern is that because I am a discordant monozygotic twin to MS, as well as my mum having MS, how likely is the severe spacticity in my feet (regular cramping accompanied with my toes contracting together and spreading apart etc.) a sign of early onset of a CNS disease? Do you think given my circumstance I should follow up with a lumber puncture etc? Thank you.
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1760990_tn?1313541798

Dear talee40,

Thanks for posting your query.

From the description, it looks like you have muscular cramps, stiffness in the legs and diffuse fasciculations with episodic weakness of the left upper limb indicating multiple neuraxis involvement (that means that multiple neural pathways are involved). To add, a magnetic resonance imaging scan (MRI scan) does not show any evidence for ALS or brain and spinal cord demyelination. So I personally feel you are not suffering from multiple sclerosis or amyotrophic lateral sclerosis (ALS). However I would be interested in confirming the findings by a good clinical examination. If confirmed, then further investigations would be required in you based on the syndrome. If the neurological examination is normal, no further work up is required.

Regarding the risk of contracting multiple sclerosis, it is 1 in 50, if your mother has the disease. If you are a discordant monozygotic twin, risk of having multiple sclerosis, is approx 4%. However these statistics do not mean that you will definitely get the disease.

I am sorry you are dealing with this frustrating concern and I hope you can find yourself in better health soon with the help of your neurologist.

I personally feel you do not have MS or ALS and it is possible that your symptoms are related to excessive anxiety (since you already have a family history of multiple sclerosis). Measures to reduce anxiety like deep breathing, yoga, meditation will help. If it doesn’t become ok consult your physician who can prescribe some anti-anxiety medication. However, the above measures will hold good only after we have done a good clinical examination.

Let me know if I have missed out any other concern in your question. Yet again, I duly appreciate your query to me, I do hope that you have found something useful to help you and I shall be glad to answer any further apprehensions.

Hope that this information helps and hope that you will get better soon.

Thank you for using MedHelp's "Ask an Expert" Service, where we feature some of world's renowned medical experts in their fields. Millions have benefitted from our service to get personalized advice for them and for their loved ones.

Best Regards,
Dr. Shiva Kumar R
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