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Neurology  (Expert Forum)
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3 Conditions? Or One?
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3 Conditions? Or One?

by Ruth__0__0, Dec 30, 1998 12:00AM

  Hello,

  I am being, or have been, treated for 3 different conditions, the medications for which all seem to involve neurotransmitter regulation,
  namely, migraine (Imitrex), depression (not currently on medication, but
  have taken Prozac & Zoloft in the past) and obesity.  I have noticed that these 3 different conditions (& treatments therefore) really do seem to interact with one another to a great extent.  In fact I'd say they are intimately intertwined (eg, I gained 90 lbs on elavil which was once prescribed for depression, and which I see is now being used for migraine
  prevention;  another example:  when I need to use Imitrex, it
  very clearly has an effect on my depression, too, if I happen to
  be suffering from a bout of depression at that time).  The one medication
  I have ever used that seemed to control *all three* conditions
  at once was fenfluramine, which was prescribed by an obesity specialist (I lost weight, was not depressed, and had NO migraines while I was on the medication).  But then of course that medication was taken off the market.

  I am starting to have a theory about these 3 conditions, ie,
  that it is not 3 *different* problems, but rather that there
  is one single underlying problem (with the brain neurotransmitter
  regulating mechanism??), which, if that ONE problem were
  adequately addressed, all the various manifestations of it
  (obesity, depression, migraine) would resolve.  The problem
  is that I have 4 different drs involved (psychiatrist for
  depression (who I only see once/yr), obesity specialist for obesity, neurologist for migraine, and my primary care physician who is a family
  practice specialist) and none of them are really interested in the problems that supposedly fall under the "venue" of one of the other specialists.  (ie, neurologist not interested in obesity; bariatric specialist not interested in migraine; etc., etc., etc.) - and my primary care physician just keeps referring me back to the various specialists.  This all
  seems too fragmented to me.  And its Frustrating!

  What kind of dr (a neurologist? that's my best guess) would be
  interested in possibly looking into the possibility that these
  are not 3 *different* disorders, but maybe ONE underlying
  disorder that precipitates "symptoms" from all 3 of these
  allegedly different areas of specialization?

  I was SOOOOOO disappointed when they took fenfluramine off the
  market.  Although all my various specialists have tried various
  different medications & lifestyle modification recommendations,
  etc., etc., I have never (either before or since) in my adult
  life had all 3 of these conditions under control at once, as I
  did when on that medication.  But now that I know that it is
  POSSIBLE to have all 3 of them under control at once, I want
  very much to achieve that again, somehow.  I'm just at a loss
  for what kind of dr would be the right kind of dr to see who would
  be interested in the whole total picture & not just their own one little
  part of it.

  Thank you very much for your response;  I really appreciate it.
========================================================================================
Thanaks for the question. It is always possible that the diet medication may be brought back on the market although I have seen nothing yet. I have heard reports that the cardiac complications may have been overestimated? So you may have some luck in that regard. Interstingly the disease processes you discuss have mostly to do with the serotonergic system and I'm sure that an interaction exists between the three problems. The fenfluramine was thought to act by also affecting serotonin levels. How it put everything in homeostasis for you I am not sure. In terms of a doctor who can put this togeathert for you it will be a matter of finding someone who will take a holistic approach and it may require alittle searching around and discussion with friends. Good luck
This information is provided for general medical education purposes only. Please consult your doctor regarding diagnostic and treatment options.




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