Neurology Community
Ambien, GABA and Dystonia
About This Community:

This forum is for questions and support regarding neurology issues such as: Alzheimer's Disease, ALS, Autism, Brain Cancer, Cerebral Palsy, Chronic Pain, Epilepsy, Headaches, MS, Neuralgia, Neuropathy, Parkinson's Disease, RSD, Sleep Disorders, Stroke, Traumatic Brain Injury.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Ambien, GABA and Dystonia

I was diagnosed with Focal Dystonia in my wrist a few months ago. Since then it has become multifocal, affecting both feet and hands.

I was prescribed with Trihexyphenidyl which wasn't working very well so I quit taking it.

But, a week ago, I was prescribed to Ambien. After I took it I noticed that my dystonia disappeared shortly after. I tested this again by taking half a pill during the day and my dystonia disappeared again. Same thing the next day.

Is this suprising?

Since Ambien is having such a positive effect on my dystonia maybe someone could suggest another drug that affects GABA like Ambien?

Thanks.
Related Discussions
2 Comments Post a Comment
Blank
Avatar_n_tn
I have Dystonia also and was prescribed Ambien. I feel great in the morning when I wake up. I  dissapeares after an hour or so and goes back to the spasms. I too wish they could copy a drug to take during the day. I tried 1/2 pill during the day but slept  5 hours.
Blank
Avatar_f_tn
My husband has focal dystonia in his back.  In addition to botox injections he has taken Tizanidine (Zanaflex) and Baclofen (?brand name).  He can't take Ambien, he has sleep apnea.  

Here's info from rxlist.com on Zanaflex and Baclofen:
Baclofen is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Although baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects.

Zanaflex® (tizanidine hydrochloride) is a centrally acting α2-adrenergic agonist. Tizanidine is an agonist at α2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways The overall effect of these actions is thought to reduce facilitation of spinal motor neurons

Good luck.  We're still looking for the right combination of drugs and therapy!
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Neurology Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
2 hrs ago by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank
Top Neurology Answerers
620923_tn?1405964489
Blank
selmaS
Allentown, PA
338416_tn?1260996698
Blank
jensequitur
Fort Worth, TX
1780921_tn?1384615710
Blank
flipper336
Chandler, AZ
352007_tn?1372861481
Blank
LisaJF
10389859_tn?1409925468
Blank
Foggy2
Avatar_m_tn
Blank
Ball123