Anti-seizure medication

Does anyone know how Dilantin Sodium (Phenytoin?) works?

[Dr Sharma]

Hi there. Dilantin sodium blocks voltage sensitive sodium channels in neurons which leads to a delay in neuronal electrical recovery from inactivation. It is related to barbiturates in chemical structure.It prevents the electrical spread of a focus of irritable tissue from entering normal tissue. Its toxicity depends on the route of administration, duration, exposure and dosage. The route of administration is the most important determinant of toxicity. I hope this helps.

[Dr Sharma]

Hi there. Dilantin sodium blocks voltage sensitive sodium channels in neurons which leads to a delay in neuronal electrical recovery from inactivation. It is related to barbiturates in chemical structure.It prevents the electrical spread of a focus of irritable tissue from entering normal tissue. Its toxicity depends on the route of administration, duration, exposure and dosage. The route of administration is the most important determinant of toxicity. I hope this helps.

[janeebe]

Thank you for your earlier answer.  It certainly seems like the drug for me!  How long should I be on this pre and post op to help prevent seizures?  I am due for a craniotomy shortly.

Once again, thanks for all your help.  My neurosurgeon didn't like me asking these questions.