Antiphospholipid and Clots

[Steve__0__0]

  This question comes up every once in a while among other people I know with APLS.  Has  there ever been any research into IgG values and their relationship to INR or stroke occurance?  I know in my case, my IgG levels will swing from a low of @ 100 to a high of 792.  It was at 792 that I had a stroke and heart attack.  Is there any "chart" or something which shows a likelyhood of clots to IgG ?
Dear Steve:
Thanks for your question, but as usual there is no proven correlation between strict IgG level and stroke.  However, as the level get higher, the probability of a cerebral vascular event increases but an absolute value that will give you an event is unknown.  If fact, in the fact of just an elevated level of detected antibody, there is on consensus of whether to anti-coagulate the person.  There is also likely going to be a difference between people with the Antiphosphlipid syndrome and those people with just an isolated elevated level of antibody.  For your information, the antibodies can be derived to a multitude of different proteins, not just to negatively charged lipids.  So, depending on which proteins are involved, the risk for stroke will change.  Also, the risk factors that the patients have, such as diabetes, smoking, hypertension, high cholesterol, heart disease etc. will also change the risks for stroke with antiphospholipid antibodies.  I hope that I answered your question.
Sincerely,
CCF Neuro[P] MD,RPS