Aa
A
A
Close
Avatar universal
Any Research updates?
I was diagnosed with Primary Lateral Sclerosis in 1992 and it was confirmed at the Mayo Clinic in 2000.  Most doctors here can tell me nothing about any research that is being done or the progress of such.  Has anyone out there heard anything?
Cancel
3 Answers
Page 1 of 1
Avatar universal
Hello Dear,
Primary lateral sclerosis (PLS) is a rare neuromuscular disease characterized by progressive muscle weakness in the voluntary muscles. PLS belongs to a group of disorders known as motor neuron diseases. Motor neuron diseases develop when the nerve cells that control voluntary muscle movement degenerate and die, causing weakness in the muscles they control. Onset of PLS usually occurs after age 50. Symptoms may include difficulty with balance, weakness and stiffness in the legs, and clumsiness. Other symptoms may include spasticity (sudden, involuntary muscle spasms) in the hands, feet, or legs; foot dragging, and speech problems due to involvement of the facial muscles. The disorder usually begins in the legs, but it may also start in the tongue or the hands. The disease-which scientists believe is not hereditary-progresses gradually over a number of years, or even decades. In PLS, there is no evidence of the degeneration of spinal motor neurons or muscle wasting (amyotrophy) that occurs in amyotrophic lateral sclerosis or ALS (Lou Gehrig's disease), which it resembles. Diagnosis of PLS is often delayed because it is mistaken for ALS.

Treatment for individuals with PLS is symptomatic. Baclofen and tizanidine may reduce spasticity. Quinine or phenytoin may decrease cramps. Physical therapy often helps prevent joint immobility. Speech therapy may be useful for those with involvement of the facial muscles.

PLS is not fatal.  There is no cure, and the progression of symptoms varies.  Some people may retain the ability to walk without assistance, but others eventually require wheelchairs, canes, or other assistive devices
The NINDS conducts a broad range of research on neuromuscular disorders such as PLS. This research is aimed at developing techniques to diagnose, treat, prevent, and ultimately cure these devastating diseases.
Hope this helps you
Refer http://www.ninds.nih.gov/disorders/primary_lateral_sclerosis/primary_lateral_sclerosis.htm
Best


Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
Thank you for your reply but the information you gave me, I was well aware of since I have don't alot of research myself and have gotten information from the Mayo Clinic.  

I was just wondering if there was anything NEW.
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
As you may have guessed---this is a very frustrating disease.  My family doctors don't know what this is and I end up having to educate them.  The Neurologist I see, admits that he knows very little about this and has run tests on my nerve conductivity and says he understands this issue.  He does not know how to help me except with the Zanaflex and Neurotin for the nerve pain.  

I was on so much medication that it affected my life more than the PLS.  I took myself off of it and feel human again.  I would rather have the spacity than be a zombe.
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Neurology Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Neurology Answerers
620923 tn?1452919248
Blank
Allentown, PA
5265383 tn?1465260698
Blank
ON
144586 tn?1284669764
Blank
1780921 tn?1462244109
Blank
Queen Creek, AZ
11079760 tn?1449081557
Blank
Minneapolis, MN
209987 tn?1451939065
Blank
AB