B6 (pyridoxal phosphate) levels very high in bloodwork

[ballagher]

I have been tested twice recently for B6 level.  My first test two months ago indicated a 156 level with normal range being 20-96.  My second test indicated at 283 level.  My physician has no idea what this means and if there is a problem.  I am concerned that there is a toxic level of B6 and I should be doing something about it.  I'm not talking anything except multi-vitamin.  I've been concerned about my health for some time as I'm quite fatigued, anxious at work, balance issues (the term lightheaded would be the closest) eyes are sensitive to light, have trouble focusing on people when they talk, and have a few other issues like trouble concentrating, sense of smell has been gone for years and my sense of taste has been affected for quite some time as well.  My skin is quite raw on the knuckles and I think I have psoriasis as well as my nails are pitted and raised.  Not sure what is related but I definitely feel that there is something physicially wrong with me and this high B6 level has been the first thing to come up as being something worth pursuing.  Any help would be appreciated.  

[Debra_An]

Mike and others,
You all should see a neurologist for these symptoms as they deal with things like tingling numb sensations. They should also help you decide what your options are to help. Maybe pain medication or some other medication. Depending what they find will depend on what they can or will do for you as each person is different with different issues.
Best wishes to all.
Debra An

[psarv]

HI have your symptoms gotten better? Did you ever find out if it was something else beside the b6?

[marykays]

I stumbled upon this thread and am happy to find anyone who can sympathize with me and possibly help me.I have spent the last several years seeing numerous doctor's who haven't been able to figure out what's going on.My newest labs show very high b6.They thought it was a lab error but after 3 tests it isn't. I take no vitamins or prescriptions,not even Tylenol.I have low D,MTHFR double mutation,gluten and soy intolerance.I'm in constant pain.I used to workout daily and now can't even go up the stairs without joing pain.If I do try to work out I get severe muscle spasms afterwards for days.I can't even play with my kids.I have drained my savings account and spent thousands of dollars on doctors and tests.I just can't do it anymore.Any suggestions would be greatly appreciated.  

[maryb62]

Had you, before you experienced the symptoms, taken a fluoroquinolone anitbiotic, i.,e., cipro, levaquin or the generic equivalent for a sinus infection or some such?  Your problems sound just like mine which were a result of a toxic reaction to levaquin.  Look up the side effects.  Wishing that you feel better soon.

[m_artifact]

I have B6 toxicity.  It was first induced with supplements.  It took 8 - 10 months to clear up.  I then had a recurrence simply from eating scrambled eggs and pistachios (both high in B6)! No supplements.  I got it cleared up for a couple yrs by avoiding foods high in B6 and strictly avoiding any supplemental B6.  Then it recurred again when I took just a few B-complex caps over the course of several weeks.

I have Lyme disease and Babesia, and have been treated with a fluoroquinolone abx.  Strangely, I took a multivitamin for many years and never had B6 toxicity occur until Lyme disease became crippling and was being treated.

[NDBMom]

Hi Chiasma,

I have hashimoto's and hypo, MTHR mutations, and high B5 and B6 too. I am trying to figure out what can be done as well.

NDBMom

[Anne808]

I came across this forum by looking up pyrroles disease (aka pyroluria), b6 and zinc deficiencies. I don't know if any of you have heard of pyrroles disease, it seems as though it has only recently been brought attention.

"Pyroluria (Pyrrole disorder) is characterized by an elevated urine kryptopyrrole, which results in a dramatic deficiency of zinc and Vitamin B6. It is a blood disorder, which is genetically transmitted. Because of an abnormality in the synthesis of hemoglobin, a chemical imbalance occurs in the blood. Diagnosis can be made by urine laboratory testing. Treatment consists of Vitamin B6 and zinc."

Testing for pyroluria requires a non-standard urine test that only few labs can do at the moment, however, it seems as though some of you have unusual b6 and zinc levels. Pyroluria has also been associated with MTHFR gene.
http://www.drlam.com/blog/pyroluria-and-adrenal-fatigue-syndrome/5273/
http://mthfr.net/mthfr-mutation-consider-these-laboratory-tests/2012/01/02/

I hope this helps someone.

[NHNow]

Thanks all for your effort and time to share.

Could this condition (High B6 and sometimes low Vit D) be as a result of some infection ?