Bob can you tell me what this diagnosis means

bob, could you tell me what this means? sevvere progressive cervical myelopathy with a B12 deficiency. a paraneoplastic autoantibody screen showed elevated ganglionic acetylcholine receptor antibodies. The level was 0.05 with the normal being 0.02 or below. Some of the evaluation, including CRMP-5 Western blot, are still pending. This may be significant given the other normal findings. The vitamin E, TPO antibodies, gastrin levels, lyme screen, syphilis screen, HIV, HTLV,-1, HTLV-2, zinc levels, and methylmalonic acid levels were all negative or normal. The ceruloplasmin was mildly suppressed at 16.3. The copper level was only minimally reduced at 0.71. A colleague who has a special interest in copper dificiency myelopathy, felt that it was unlikely to be significant. The urine heavy metal screen was negative, the TSH was minimally elevated at 5.3. Her CT scan showed a small nodule but was otherwise unremarkable. Her MRI showed 1 lesion in the brain and a lesion in the spinal cord (neck area) that from the 2nd vertebra to the 6th vertebra had total demyelination.
  If you could help me understand this I would appreciate it greately. These findings were mailed to us as we could not stay at the Mayo Clinic long enough to get this in person.
   Thank you
    carol

[BobbHilton]

Hi,
  (Sevvere progressive cervical myelopathy) pathy SIMPLY  means disease.., if linked to  vit B12 deficiency means specific severe features seen on the back part of your cervical spine suggestive of B12 def

  Sorry, I'm not aware of doing  a paraneoplastic autoantibody screen for ganglionic acetylcholine receptor antibodies? we usually do  voltage-gated calcium channels antibodies (foe Myasthenic syndrome!!)
    acetylcholine receptor antibodies are 3 types and detected in 80-85% of Myasthenia gravis and ~50-60 of occular myasthenia

  " A colleague who has a special interest in copper dificiency myelopathy, felt that it was unlikely to be significant"
A VERY SMART COLLEAGUE, BECAUSE MORE AND MORE ARE BEING PUBLISHED ABOUT COPPER DEFICIENCY...BUT GENERALLY THE ANSWER WOULD COME AFTER REPLACING YOUR COPPER LEVEL!! IF THAT MADE YOUR CASE BETTER!!

    " the TSH was minimally elevated at 5.3" YOU NEED TO DO fREE t4,  T3 AND rT3 LEVEL..THIS IS MOST LIKELY SICK EUTHYROID SYNDROME (MEANING NO THYROID DISEASE)

   "Her CT scan showed a small nodule but was otherwise unremarkable " CT OF WHAT? IF THE THYROID THEN BETTER DO DISCUSS WITH AN ENDORINOLOGIST , SHE MAY NEED FURTHER TESTING!!!

    "Her MRI showed 1 lesion in the brain and a lesion in the spinal cord (neck area) that from the 2nd vertebra to the 6th vertebra had total demyelination " WE DISCUSSED THAT BEFORE ! AT THIS TIME SHE NEEDS TO BE TREATED FOR THE LOW b12 AND THE COPPER, AND FOLLOW UP THE REST OF THE RESULTS

   God bless
   Bob Hilton