CSF results

[janspoko]

I wrote to you on January 7th about my MRI showing multiple lesions in the white matter.  Most were inactive only one being active at the time.  My results on the VEP absolute P-100 were 119 and 120.

Yesterday I received the results of my LP.  Everything was within the normal range.  However, the gamma globulin was 8.8 which was within the normal range of 3.0-13.0 but beneath this was a note that reads as follows:

Single faint abnormal protein band detected in the gamma globulins.  Oliogoclonal gamma globulin analysis is available if clinically indicated.

Could you please explain this to me.  Also, does this allow my neurologist to make a definite MS diagnosis?

Thank you for your wonderful site and your taking your time to help those of us who call on you.

[CCF-Neuro-M.D.-CS]

When analyzing spinal fluid to look for abnormal anti-body production (such as in MS) you have to compare the amount produced in the blood compared to the spinal fluid. An elevated level is suggestive of a possible auto-immune disease. Typically one also checks for oligo-clonal bands, which are abnormal levels of one specific type of anti-body although the total level may be normal. Oligoclonal bands are present in 80-85% of patients with MS. Therefore, I think the report was suggesting that an oligoclonal band be checked.

If your spinal fluid is positive, your clinical history is suggestive, and your MRI has white matter lesions, then yes a diagnosis of MS can be made. Good luck.