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Neurology (Expert Forum)
Cavenous Angioma - Hereditary?
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Cavenous Angioma - Hereditary?
by Tate Susan, Jan 17, 2005 12:00AM
My son suffered grand mal seizures from age 9 to 21. Univ of Mich diagnosed a cavenous angioma and performed miraculous surgery in 1996. He has required no medication and suffered no ill effects. Since that time, his Uncle and his Father have been diagnosed with cavenous angioma. The Uncle had grand mal seizure onset at age 55 and has had successful surgery, and the father's surgery (age 53) is pending - he's had no seizure activity - only headache and visual disturbances.
Is this hereditary? What are medical chances that my son's children and/or his brother will eventually be diagnosed with this same condition? Should they be tested? Are the females in the family as at-risk as the males? Will my son develop additional cavenous angioma's?
Is this hereditary? What are medical chances that my son's children and/or his brother will eventually be diagnosed with this same condition? Should they be tested? Are the females in the family as at-risk as the males? Will my son develop additional cavenous angioma's?
Doctor's Answer
by CCF-Neuro-M.D.-CS, Jan 18, 2005 12:00AM
I cannot give you formal genetic counselling, and you should seek a Geneticist or genetic counsellor within your healthcare system who can
In the medical literature/experience, familial cavernous angioma (that is, occurring in multiple members of the same family) is inherited as an 'autosomal dominant trait with variable expressivity' - you would need to discuss this with the genetic counsellor to understant this term. In general it means that it could be inherited to the next generation, but it may not. I cannot give any percentages (but definitely 50% chance or below). Males and females could be effected with this mode of inheritance.
I cannot confirm that this mode of inheritance that I have desribed is definetely the one in your family, again, a genetic counsellor can be more confirmatory
I do not have any information on whether they could occur again after being removed, I imagine this would be extremely rare.
You should consult with your sons to see if they would like more information, as I do not want to give them any information that they do not want to know about.
In any case, there is no standard genetic test for this condition, although there may be in the future.
In the medical literature/experience, familial cavernous angioma (that is, occurring in multiple members of the same family) is inherited as an 'autosomal dominant trait with variable expressivity' - you would need to discuss this with the genetic counsellor to understant this term. In general it means that it could be inherited to the next generation, but it may not. I cannot give any percentages (but definitely 50% chance or below). Males and females could be effected with this mode of inheritance.
I cannot confirm that this mode of inheritance that I have desribed is definetely the one in your family, again, a genetic counsellor can be more confirmatory
I do not have any information on whether they could occur again after being removed, I imagine this would be extremely rare.
You should consult with your sons to see if they would like more information, as I do not want to give them any information that they do not want to know about.
In any case, there is no standard genetic test for this condition, although there may be in the future.
